{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:30Z","timestamp":1753868670926,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melanoma is rare as a secondary malignant neoplasm among childhood cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We report a case of a 12\u2010year\u2010old boy who developed malignant melanoma with systemic metastases 17\u2009months after completing treatment for hepatoblastoma. The diagnosis was made unexpectedly based on a bone marrow examination. The patient did not respond to immune checkpoint inhibitor therapy and died 6\u2009weeks after being diagnosed with melanoma. Whole\u2010exome sequencing to examine 103 genes associated with cancer predisposition did not identify any germ\u2010line variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case study provides a unique example of melanoma in a childhood cancer survivor following hepatoblastoma treatment but does not identify any candidate variant to link hepatoblastoma and melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2118","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T12:29:58Z","timestamp":1716812998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant melanoma in a 12\u2010year\u2010old boy 17\u2009months after completing hepatoblastoma treatment"],"prefix":"10.1002","volume":"7","author":[{"given":"Koji","family":"Kanezawa","sequence":"first","affiliation":[{"name":"Pediatrics Nihon University Itabashi Hospital  Tokyo 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