{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:13:55Z","timestamp":1767892435444,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>SMARCA4<\/jats:italic> is a component gene of the SWI\/SNF (SWItch\/Sucrose NonFermentable) chromatin remodeling complex; undifferentiated tumors associated with its functional deletion have been described in several organs. However, no established treatment for these tumors currently exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>In this study, we report a case of a SMARCA4\u2010deficient undifferentiated urothelial carcinoma with high PD\u2010L1 expression that was effectively treated with nivolumab after early relapse following treatment for non\u2010invasive bladder cancer. The histological morphology of the rhabdoid\u2010like undifferentiated tumor of unknown primary led us to suspect a SWI\/SNF\u2010deficient tumor, and subsequent immunostaining led to the diagnosis of a SMARCA4\u2010deficient undifferentiated tumor. This effort also led to the identification of the developmental origin of this SMARCA4\u2010deficient undifferentiated tumor as a non\u2010invasive bladder cancer. We also carried out a detailed immune phenotypic assay on peripheral T cells. In brief, a phenotypic change of CD8+T cells from naive to terminally differentiated effector memory cells was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regardless of the organ of cancer origin or cancer type, SWI\/SNF\u2010deficient tumors should be suspected in undifferentiated and dedifferentiated tumors, and immune checkpoint inhibitors may be considered as a promising treatment option for this type of tumor. The pathogenesis of SMARCA4\u2010deficient anaplastic tumors awaits further elucidation for therapeutic development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2127","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:49:25Z","timestamp":1719226165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Marked Response to Nivolumab by a Patient With <scp>SMARCA4<\/scp>\u2010Deficient Undifferentiated Urothelial Carcinoma Showing High <scp>PD<\/scp>\u2010<scp>L1<\/scp> Expression: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7673-3724","authenticated-orcid":false,"given":"Yohei","family":"Arihara","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sapporo Medical University School of Medicine  Sapporo 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