{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:26Z","timestamp":1753868666707,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies regarding infectious causes of febrile neutropenia (FN) in Mexico are available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to describe clinical and microbiological characteristics of FN episodes during induction chemotherapy in adults with acute leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This retrospective cohort from a Mexican tertiary care center included adults with newly diagnosed acute leukemia between January 2014, and December 2018. Clinical and microbiological characteristics were summarized using descriptive statistics. Univariate analyses for associations between clinical characteristics and FN and\/or death were made; logistic regression analysis was performed to assess relationships with FN. Kaplan\u2013Meier survival estimates were modeled for antimicrobial prophylaxis and FN. Ninety\u2010five patients were included. Median age was 28 (IQR 20\u201343), 49 (52%) were males, and 74 (78%) developed FN (74\/95). Among these, 98% had an identified source of infection (73\/74) and 65% had &gt;1. Common infections were urinary tract infection (24%), bacterial sinusitis (20%), and bacterial pneumonia (19%). Gram\u2010negatives were the most frequently isolated microorganisms (69%), followed by Gram\u2010positives (21%), and fungi (9%). Antimicrobial prophylaxis was inversely associated with FN (aOR = 0.07, CI 0.008\u20130.060, <jats:italic>p<\/jats:italic> = 0.02). Invasive fungal diseases were associated with 30\u2010day mortality (aOR = 9.46, 95% CI 1.66\u201354.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infections caused 98% of the FN episodes. Gram\u2010negative bacteria are the most common pathogens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2129","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T12:14:13Z","timestamp":1724069653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Microbiological Characteristics of Febrile Neutropenia During Induction Chemotherapy in Adults With Acute Leukemia"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7809-9619","authenticated-orcid":false,"given":"Sandra","family":"Rajme\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea\u00a0C.","family":"Tello\u2010Mercado","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Ort\u00edz\u2010Brizuela","sequence":"additional","affiliation":[{"name":"Internal Medicine Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo\u00a0A.","family":"Mart\u00ednez\u2010Guerra","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla\u00a0M.","family":"Tamez\u2010Torres","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla\u00a0M.","family":"Rom\u00e1n\u2010Montes","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda\u00a0F.","family":"Gonz\u00e1lez\u2010Lara","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"},{"name":"Clinical Microbiology Laboratory Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Ponce\u2010de\u2010Le\u00f3n","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050091"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/383050"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-010-0029-z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.08.004"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-014-0451-8"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.12.006"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw325"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(00)00080-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2014.07.021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1884067"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1085"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-021-00387-8"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i1.42"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-018-0219-9"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/650482"},{"volume-title":"R: A Language and Environment for Statistical Computing","year":"2023","author":"R Core Team","key":"e_1_2_12_22_1"},{"issue":"6","key":"e_1_2_12_23_1","first-page":"459","article-title":"Acute Lymphoblastic Leukemia: Experience in Adult Patients Treated With hyperCVAD and 0195 Protocol, at the Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n. Cohort 2003\u20102007","volume":"60","author":"Arteaga\u2010Ortiz L.","year":"2008","journal-title":"Revista de Investigaci\u00f3n Cl\u00ednica"},{"issue":"2","key":"e_1_2_12_24_1","first-page":"55","article-title":"Update on the Management of Febrile Neutropenia in Hematologic Patients","volume":"32","author":"Escrihuela\u2010Vidal F.","year":"2019","journal-title":"Revista Espa\u00f1ola de Quimioterapia"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1513"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0333-z"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.12.006"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08058-6"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw325"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2015.409"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv343"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12133"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy825"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.2129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T02:57:01Z","timestamp":1724813821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.2129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/cnr2.2129"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.2129","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2129"}}