{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:33Z","timestamp":1753868673537,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In ovarian and other cancers, low muscle mass and density are associated with poorer clinical outcomes. However, screening for cancer\u2010related sarcopenia (typically defined as low muscle mass) is not routinely conducted. The European Working Group on Sarcopenia in Older People (EWGSOP) recommends an algorithm for sarcopenia screening and diagnosis in clinical settings, with sarcopenia based on muscle strength and mass, and severity on physical performance. We explored the application of the EWGSOP2 algorithm to assess sarcopenia in six ovarian cancer patients receiving neoadjuvant chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed sarcopenia risk with the SARC\u2010F screening questionnaire (at risk \u22654 points), muscle strength with a handgrip strength test (cut point &lt;16\u2009kg) and five times sit\u2010to\u2010stand test (cut point &gt;15\u2009s), muscle mass by skeletal muscle index (SMI in cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> from a single computed tomography [CT] image; cut point &lt;38.5\u2009cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>), and physical performance with a 4\u2010m gait speed test (cut point \u22640.8\u2009m\/s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of six participants, none were identified as \u201cat risk\u201d for sarcopenia based on SARC\u2010F scores. Two participants were severely sarcopenic based on EWGSOP2 criteria (had low muscle strength, mass, and physical performance), and five participants were sarcopenic based on muscle mass only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Ovarian cancer patients with low muscle mass during neoadjuvant chemotherapy may not be identified as sarcopenic based on the EWGSOP2 diagnostic algorithm. While lacking a universally accepted definition for cancer\u2010related sarcopenia and cancer\u2010specific recommendations for the screening, diagnosis, and treatment of sarcopenia, ovarian cancer clinicians should focus on the diagnosis and treatment of low muscle mass and density.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.2155","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T04:18:26Z","timestamp":1723177106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Sarcopenia in Advanced\u2010Stage Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Case Series"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-0287","authenticated-orcid":false,"given":"Christelle","family":"Schofield","sequence":"first","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University  Joondalup Western Australia 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