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Traditionally, prostate cancer is initially tested for through a prostate serum antigen (PSA) test and a digital rectum examination (DRE), followed by confirmation through an invasive prostate biopsy. The DRE and biopsy are uncomfortable for the patient, so less invasive, accurate diagnostic tools are needed. Current diagnostic tools, along with genes that hold possible biomarker uses in diagnosis, prognosis and indications for personalised treatment plans, were reviewed in this article.<\/jats:p><\/jats:sec><jats:sec><jats:title>Recent Findings<\/jats:title><jats:p>Several genes from multiple families have been identified as possible biomarkers for disease, including those from the MYC and ETS families, as well as several tumour suppressor genes, Androgen Receptor signalling genes and DNA repair genes. There have also been advances in diagnostic tools, including MRI\u2010targeted and liquid biopsies. Several personalised treatments have been developed over the years, including those that target metabolism\u2010driven prostate cancer or those that target inflammation\u2010driven cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several advances have been made in prostate cancer diagnosis and treatment, but the disease still grows year by year, leading to more and more deaths annually. This calls for even more research into this disease, allowing for better diagnosis and treatment methods and a better chance of patient survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70016","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T07:51:49Z","timestamp":1729065109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prostate Cancer: A Review of Genetics, Current Biomarkers and Personalised Treatments"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-5878","authenticated-orcid":false,"given":"Trevor K.","family":"Wilson","sequence":"first","affiliation":[{"name":"Discipline of Genetics, School of Life Sciences, College of Agriculture, Engineering, and Science University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9741-4124","authenticated-orcid":false,"given":"Oliver T.","family":"Zishiri","sequence":"additional","affiliation":[{"name":"Discipline of Genetics, School of Life Sciences, College of Agriculture, Engineering, and Science University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.36255\/exonpublications.prostatecancer.epidemiology.2021"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030361"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-016-0137-7"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2017.11.001"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0693"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1345"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20881"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.315739.118"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1965810"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2953"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175730"},{"key":"e_1_2_15_13_1","first-page":"1","volume-title":"Advances in Cancer Research","author":"Knudsen B. 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