{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:47:11Z","timestamp":1791935231249,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Squamous cell carcinoma (SCC) is a rare malignancy of invasive epithelium with keratinocyte differentiation, and it is the most common form of eyelid malignant neoplasm, comprising 5%\u201310% of malignancies. While SCC rarely affects the orbit, it may be involved through local invasion from a cutaneous primary site or extension by perineural invasion. Only 12 cases of primary orbital SCC have been reported until now. Here, we present a case of primary carcinoma of the right orbit with coexisting Carney's syndrome, a rare genetic disorder associated with multiple endocrine neoplasias (MEN) syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 62\u2010year\u2010old South Asian male presented with a painful swelling in the lateral aspect of the right eyebrow and protrusion of the eyeball in August 2020. He had a history of excision of Right atrial Myxoma in March 2020. Orbital computerized tomography (CT) and positron emission tomography (PET\u2010CT) scans revealed an enhancing soft tissue lesion in the right orbit with the involvement of frontal and ethmoid sinuses. Biopsy confirmed HPV\u2010related poorly differentiated SCC, positive for HPV\u2010related markers. The patient received concurrent chemo irradiation with Cisplatin. Follow\u2010up PET\u2010CT done 3\u2009months later showed a new lesion appeared in the right orbital region and right lobe of thyroid. Later had surgical excision and total thyroidectomy, and histopathological examination (HPE) from orbit was reported as invasive SCC and from the thyroid was reported as synchronous papillary thyroid cancer. The patient's proptosis resolved, and subsequent PET\u2010CT and magnetic resonance imaging (MRI) scans did not show any residual or recurrent disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary SCC of the orbit is an extremely rare disease, and this case report presents the 13th reported case and the first one associated with Carney's syndrome. As there is no standard treatment regimen for primary SCC of the orbit, this case highlights the use of multimodality treatment, including surgical excision and chemo irradiation. The findings emphasize the importance of early detection and management of this uncommon and life\u2010threatening condition, providing hope for patients and aiding in the prevention of recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70020","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T12:16:53Z","timestamp":1727353013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Primary Squamous Cell Carcinoma of the Orbit in a Patient With Carney's Syndrome Treated With Multidisciplinary Approaches"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7912-4430","authenticated-orcid":false,"given":"Md. Arifur","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Oncology Bangladesh Specialized Hospital Limited  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-9716","authenticated-orcid":false,"given":"Rajesh","family":"Balakrishnan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology CMC Vellore  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Golam","family":"Mostofa","sequence":"additional","affiliation":[{"name":"Department of Histopathology Anowara Medical Service  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4939-6971","authenticated-orcid":false,"given":"Mohammed Rashedul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery BIRDEM General Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enamul","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Physics Delta Medical College Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shariful","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Physics Delta Medical College Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidoura","family":"Naznin","sequence":"additional","affiliation":[{"name":"Department of Oncology Square Hospitals Limited  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunangshu","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Oncology Square Hospitals Limited  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qamruzzaman","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Oncology Bangladesh Specialized Hospital Limited  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(05)80054-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90161-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(86)90089-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800070090015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2011.02517.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e31822ddd91"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000048"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3341\/jkos.2014.55.8.1224"},{"key":"e_1_2_9_10_1","first-page":"37","article-title":"Primary Orbital Squamous Cell Carcinoma","volume":"77","author":"Campos Arbulu A. L.","year":"2017","journal-title":"Medicina"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490060"},{"key":"e_1_2_9_12_1","article-title":"Primary Squamous Cell Carcinoma, Orbital Site: A Case Study and Systematic Review","volume":"12","author":"El Samkary M.","year":"2021","journal-title":"Journal of Clinical and Experimental Ophthalmology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8585692"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/SJOPT.SJOPT_11_23"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"37","article-title":"Primary Orbital Squamous Cell Carcinoma","volume":"77","author":"Campos Arbul\u00fa A. L.","year":"2017","journal-title":"Medicina"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.11S2a168S"},{"key":"e_1_2_9_17_1","volume-title":"StatPearls [Internet]","author":"Vindhyal M. 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