{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:56:31Z","timestamp":1782964591437,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We explored associations between plasma protein levels and fever\u2010 and infection\u2010related complications in 26 AML patients during chemotherapy\u2010induced neutropenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Longitudinal plasma profiling was conducted using data\u2010dependent mass spectrometry analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mass spectrometry\u2010based plasma profiling data correlated well with laboratory parameters, including C\u2010reactive protein, and revealed a broader inflammation protein network associated with fever\u2010 and infection\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70024","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:25:56Z","timestamp":1729697156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plasma Profiling of Acute Myeloid Leukemia With Fever\u2010 and Infection\u2010Related Complications During Chemotherapy\u2010Induced Neutropenia"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3595-992X","authenticated-orcid":false,"given":"Iris C.","family":"Kreft","sequence":"first","affiliation":[{"name":"Department of Molecular Hematology Sanquin Research  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"van de Geer","sequence":"additional","affiliation":[{"name":"Department of Blood Cell Research, Division Research and Landsteiner Laboratory of Amsterdam UMC Sanquin Blood Supply  Amsterdam The Netherlands"},{"name":"Department of Pediatric Immunology, Rheumatology and Infectious Diseases Emma Children's Hospital, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva R.","family":"Smit","sequence":"additional","affiliation":[{"name":"Department of Molecular Hematology Sanquin Research  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"van der Zwaan","sequence":"additional","affiliation":[{"name":"Department of Molecular Hematology Sanquin Research  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris P. 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