{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:32Z","timestamp":1753868672774,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cancer incidence in the Galapagos archipelago is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In 2021, a task force including Ecuadorian and Italian researchers was established to estimate cancer incidence among the 25\u2009244 Galapagos residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Registration covered all malignancies, including malignant melanoma and non\u2010melanoma skin cancers; case recording was based on the International Classification of Diseases for Oncology. The data collection involved an active search across all relevant health institutions on the islands and the mainland. Mortality data were obtained from the Ecuador national mortality registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2013 and December 2019, 174 new cancer cases were recorded, including 134 malignancies (M:F\u2009=\u200958:76) and 40 non\u2010melanoma skin cancers. The mean age at diagnosis was 48\u2009years for males and 56\u2009years for females. Prostate, gastric, and melanocytic malignancies were most incident among males; breast, thyroid, and cervical cancers prevailed in females. The age\u2010standardized incidence rates (ASR) were 80.39 for males and 99.24 for females with a mortality\u2010to\u2010incidence ratio 0.43. These ASRs were significantly lower than those reported in continental Ecuador and other South American countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This pilot cancer registration initiative in the Galapagos record a low incidence of malignancies and requires validation with temporal expansion of cancer registration. The environmental etiology of some of the most common cancers warrants strategic primary and secondary prevention efforts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70028","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T15:39:22Z","timestamp":1735227562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Incidence of Cancer Recorded in the Galapagos Archipelago"],"prefix":"10.1002","volume":"7","author":[{"given":"Stefano Nicolas","family":"Chisesi","sequence":"first","affiliation":[{"name":"Angela Serra Association for Cancer Research  Pierto Baquerizo Moreno, San Cristobal, Galapagos Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-0563","authenticated-orcid":false,"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit University of Padova  Padova Italy"},{"name":"Veneto Cancer Registry Azienda Zero of the Veneto Region  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Raffaella","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Manni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica Mishell Luzuriaga","family":"Delgado","sequence":"additional","affiliation":[{"name":"Angela Serra Association for Cancer Research  Pierto Baquerizo Moreno, San Cristobal, Galapagos Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodoro","family":"Chisesi","sequence":"additional","affiliation":[{"name":"Angela Serra Association for Cancer Research  Pierto Baquerizo Moreno, San Cristobal, Galapagos Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Ruiz","sequence":"additional","affiliation":[{"name":"University of Specialties Esp\u00edritu Santo  Guayaquil Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina Mariuxi Quinto","family":"Briones","sequence":"additional","affiliation":[{"name":"Departamento de Campa\u00f1a Preventiva of Guayaquil  Guayaquil Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Siculella","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Guzzinati","sequence":"additional","affiliation":[{"name":"Veneto Cancer Registry Azienda Zero of the Veneto Region  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Veneto Cancer Registry Azienda Zero of the Veneto Region  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Federico","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Iannone","sequence":"additional","affiliation":[{"name":"Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"volume-title":"Demograf\u00eda y estructura social en Gal\u00e1pagos: 1990\u20132008","year":"2008","author":"Larrea Maldonado C. 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