{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:03:57Z","timestamp":1769267037004,"version":"3.49.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with malignant ascites and even observed widespread metastasis or distant spread.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to develop and identify radiomics models according to computed tomography (CT) for preoperative prediction of <jats:italic>CXCL10<\/jats:italic> expression and prognosis in patients with OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genomic data with CT images and corresponding clinicopathological parameters were extracted from The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA). To analyze the prognosis, we carried out the univariate Cox regression analysis (UCRA), multivariate Cox regression analysis (MCRA), and Kaplan\u2013Meier (KM) analysis. For the data reduction, logistic regression, operator regression, least absolute shrinkage selection, radiomic feature construction, and feature selection were utilized. The predictive performance of the radiomic signatures was assessed using the analyses of the receiver operating characteristic (ROC) curve, decision curve (DCA), and precision\u2010recall (PR) curve. To evaluate the correlation between the radiomic score (Rad\u2010score) and <jats:italic>CXCL10<\/jats:italic> expression, the Wilcoxon rank\u2010sum test was applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three radiomics models effectively predicted <jats:italic>CXCL10<\/jats:italic> expression levels (AUC\u2009=\u20090.791, 0.748, and 0.718 for the set of training; AUC\u2009=\u20090.761, 0.746, and 0.701 for the set of validation). A higher Rad\u2010score significantly correlated with upregulated <jats:italic>CXCL10<\/jats:italic> expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>CXCL10<\/jats:italic> expression can be predicted noninvasively and preoperatively via radiomic signatures based on contrast\u2010enhanced CT images.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70030","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T03:56:03Z","timestamp":1729742163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radiomics Signatures Based on Computed Tomography for Noninvasive Prediction of <i>CXCL10<\/i> Expression and Prognosis in Ovarian Cancer"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-3114","authenticated-orcid":false,"given":"Xiaohua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of 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