{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:39:08Z","timestamp":1764571148317,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immune checkpoint inhibitors have demonstrated efficacy against various cancers; however, there is a rising incidence of immune\u2010related colitis. Some cases of immune\u2010related colitis prove resistant to treatment, even with the administration of glucocorticoids or infliximab, and there is currently no established standard treatment for such cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>The patient, a 73\u2010year\u2010old male, had undergone combination therapy for malignant pleural mesothelioma for 2\u2009years, utilizing both ipilimumab (a CTLA\u20104 inhibitor) and nivolumab (a PD\u20101 inhibitor). Unfortunately, the treatment led to side effects, specifically immune\u2010related adverse event (irAE) enterocolitis. Steroid and infliximab treatment failed to improve the patient's condition. Treatment with tacrolimus was attempted, but the patient remained unresponsive. Subsequently, 45\u2009mg of upadacitinib, a Janus kinase (JAK) inhibitor, was administered. Symptoms improved rapidly following upadacitinib administration, and endoscopy also revealed positive results. With the increasing incidence of immune\u2010related colitis, some patients have become resistant to treatment with glucocorticoids and infliximab. In this case, the irAE enterocolitis was improved by upadacitinib administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In cases where immune\u2010related colitis proves resistant to treatment with glucocorticoids, infliximab, or tacrolimus, upadacitinib represents a potential option as a JAK inhibitor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70032","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T03:13:42Z","timestamp":1730171622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>JAK<\/scp> Inhibitor Upadacitinib Induces Remission in Refractory Immune\u2010Related Colitis Triggered by <scp>CTLA<\/scp>\u20104 and <scp>PD<\/scp>\u20101 Inhibitor Combination Therapy in Malignant Pleural Mesothelioma: A Case 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