{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:28:06Z","timestamp":1776356886570,"version":"3.51.2"},"reference-count":74,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Hepatocellular carcinoma (HCC) is a type of malignant tumor and the sixth leading cause of death worldwide. It is caused by HBV, HCV infection, and alcohol consumption. MicroRNAs are typically small, non\u2010coding RNAs that are involved in the regulation of mRNA expression. Recent studies revealed miRNAs' regulatory roles in liver cancer, linked to risk factors like HCV, HBV infection, alcoholism, drug use, and auto\u2010immune hepatic disorders. Circular RNAs also belong to the class of non\u2010coding RNAs; they act as ceRNAs to regulate miRNA expression and regulate different oncogenic pathways in HCC progression. This study aimed to check the hsa_circ_0070269, circ\u2010102,166 (hsa_circ_0004913), and miR\u2010182 expression in HCV induced HCC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data analysis was used to find out studies related to the role of hsa_circ_0070269, circ\u2010102,166, and miR\u2010182 in HCC; miR\u2010182 targeted genes, their role in different diseases; and miR\u2010182 interactions with hsa_circ_0070269 and circ\u2010102,166 in the HCC. It was revealed that the hsa_circ_0070269, circ\u2010102,166, and miR\u2010182 correlations in HCV induced HCC have not been explored yet. Therefore, to validate data from literature mining, expression analysis of dysregulated hsa_circ_0070269, circ\u2010102,166, and miR\u2010182 was performed in HCV induced HCC patients using RT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was found that miR\u2010182 was significantly upregulated and acts as an oncomiRNA in HCV induced HCC, and hsa_circ_0070269 and circ\u2010102,166 were downregulated in HCV induced HCC. We have identified that miR\u2010182 relative expression level was significantly high (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0029), while has_circ_0070269 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002) and circ\u2010102,166 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.002) were significantly downregulated in HCV\u2010HCC patients as compared to expression in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data revealed that miR\u2010182 acts as an oncomiRNA in HCC development. Hsa_circ_0070269 and circ\u2010102,166 are highly expressed in healthy controls compared to HCV induced HCC patients, can sponge miR\u2010182 expression by acting as tumor suppressors, and can be used as biomarkers and targets for HCC treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70049","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T02:40:32Z","timestamp":1733107232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioinformatics and Experimental Insights Into <scp>miR<\/scp>\u2010182, hsa_circ_0070269, and circ\u2010102,166 as Therapeutic Targets for <scp>HCV<\/scp>\u2010Associated <scp>HCC<\/scp>"],"prefix":"10.1002","volume":"7","author":[{"given":"Yasmeen","family":"Ishaq","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology (IMBB) University of Lahore (UOL)  Lahore 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