{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:32Z","timestamp":1753868672598,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radiotherapy is considered an alternative treatment for unresectable or pharmacologically resistant desmoid\u2010type fibromatosis. While it results in relatively good local control, the risk of secondary malignancy remains a concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present a case of secondary osteosarcoma after carbon\u2010ion radiation therapy (CIRT). A 31\u2010year\u2010old male patient presented with left thigh pain. The tumor was located between the left gluteus maximus and gluteus medius and extended to the vastus lateralis and biceps femoris. It was diagnosed as desmoid\u2010type fibromatosis after needle biopsy. The patient was treated with several medications, including a cyclooxygenase 2 inhibitor and tamoxifen; however, his left thigh pain did not improve. He was treated with CIRT 1\u2009year after diagnosis (67.2\u2009Gy [relative biological effectiveness] 16fr\/4wks). He developed osteosarcoma of the left femur 8\u2009years later. He underwent chemotherapy and tumor excision with disarticulation of the left hip. Pulmonary metastasis was detected 6 and 17\u2009months after the definitive surgery and excised using metastasectomy. However, he died due to the recurrence of multiple pulmonary metastases 29\u2009months after the definitive surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this case, we believe that the low radiation dose to the femur may have caused secondary malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70062","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T10:08:10Z","timestamp":1732010890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary Osteosarcoma After Carbon\u2010Ion Radiotherapy for Desmoid\u2010Type Fibromatosis: A Case Report"],"prefix":"10.1002","volume":"7","author":[{"given":"Mizuki","family":"Aketo","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-2795","authenticated-orcid":false,"given":"Makoto","family":"Emori","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohichi","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Murase","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Arihara","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Murahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gunma University Graduate School of Medicine  Maebashi Japan"},{"name":"Gunma University Heavy Ion Medical Center  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-000-0038-5"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"96","article-title":"The Management of Desmoid Tumours: A Joint Global Consensus\u2010Based Guideline Approach for Adult and Paediatric Patients","volume":"127","author":"Desmoid Tumor Working Group","year":"2020","journal-title":"European Journal of Cancer"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-024-01177-5"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32921"},{"volume-title":"TNM Classification of Malignant Tumours","year":"2017","author":"Brierley J. 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