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After progression on first line chemotherapy, was administered neratinib, a pan\u2010Erb2 receptor tyrosine kinase inhibitor.<\/jats:p><jats:p>Even with central nervous system involvement at diagnosis, a durable clinical response was obtained with a PFS of 11\u2009months and no significant toxicities to manage. Best response observed during tratment was partial response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case confirms the potential efficacy of neratinib in HER2\u2010positive SDC and underlines the need to define the best therapeutic sequence and potential biomarkers for these rare patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70065","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:56:21Z","timestamp":1736988981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neratinib and the Role of Anti\u2010<scp>HER2<\/scp> Therapy in Salivary Duct Carcinoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Martina","family":"Napolitano","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology Azienda Ospedaliero\u2010Universitaria di Modena  Modena 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