{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:32Z","timestamp":1753868672851,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Synchronous occurrence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is extremely rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 67\u2010year\u2010old male was admitted to the hospital with hemoperitoneum caused by a liver mass rupture and elevated serum liver enzymes. Abdominal magnetic resonance imaging revealed a solid mass, with 38\u2009mm in maximum diameter, located in the fifth\/sixth segments of the liver, suggesting an HCC. Emergency surgery was performed and a second liver mass in the fourth segment was identified intraoperatively, with 20\u2009mm in maximum diameter. Hepatic resection of the affected segments was performed with free resection margins. Histopathological examination revealed the synchronous occurrence of HCC and ICC with a predominant ductal plate malformation pattern. The patient is still alive at 41\u2009months after its first surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with HCC, a proper intraoperative assessment is indicated, in addition to imaging investigations, to detect synchronous lesions that can change the therapeutic approach. This is the first case ever reported in the literature in which synchronous HCC and ICC with a predominant ductal plate malformation pattern were incidentally diagnosed in a patient with hemoperitoneum.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70085","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T04:46:11Z","timestamp":1739508371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Hepatocellular and Intrahepatic Cholangiocellular Carcinoma With Predominant Ductal Plate Malformation Pattern. A Case Report and Review of\u00a0the Literature"],"prefix":"10.1002","volume":"8","author":[{"given":"Rita","family":"Szodorai","sequence":"first","affiliation":[{"name":"Department of Pathology George Emil Palade University of Medicine, Pharmacy, Science and Technology  T\u00e2rgu\u2010Mure\u0219 Romania"},{"name":"Department of Pathology Clinical County Emergency Hospital  T\u00e2rgu\u2010Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u0151ke","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Department of Pathology Clinical County Emergency Hospital  T\u00e2rgu\u2010Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Department of Pathology George Emil Palade University of Medicine, Pharmacy, Science and Technology  T\u00e2rgu\u2010Mure\u0219 Romania"},{"name":"Department of Radiolology Clinical County Emergency Hospital  T\u00e2rgu\u2010Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radu Mircea","family":"Neagoe","sequence":"additional","affiliation":[{"name":"Department of Surgery George Emil Palade University of Medicine, Pharmacy, Science and Technology  T\u00e2rgu\u2010Mure\u0219 Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-5118","authenticated-orcid":false,"given":"Simona","family":"Gurzu","sequence":"additional","affiliation":[{"name":"Department of Pathology George Emil Palade University of Medicine, Pharmacy, Science and Technology  T\u00e2rgu\u2010Mure\u0219 Romania"},{"name":"Department of Pathology Clinical County Emergency Hospital  T\u00e2rgu\u2010Mure\u0219 Romania"},{"name":"Research Center for Oncology and Translational Medicine (CCOMT)  T\u00e2rgu\u2010Mure\u0219 Romania"},{"name":"Romanian Academy of Medical Sciences  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u201000240\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107819\u201012\u2010337"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010016\u20103787"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23897"},{"issue":"4","key":"e_1_2_9_6_1","first-page":"647","article-title":"Combined Liver Cell and Bile Duct Carcinoma","volume":"25","author":"Allen R. 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