{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:23:29Z","timestamp":1788474209091,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thromboembolic events are a common cause of morbidity and mortality in patients with cancer. While direct\u2010acting oral anticoagulants (DOACs) have been established as the preferred agents of anticoagulation in most patients with cancer, data in resource\u2010limited settings is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study aims to assess the comparative efficacy and safety of warfarin and rivaroxaban for cancer\u2010associated thrombosis (CAT) in a resource\u2010limited setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A single\u2010center retrospective cohort study was conducted on 201 patients who were on follow\u2010up from September 2021 to August 2023. The patients were categorized into two groups (1) warfarin and (2) rivaroxaban. They were then retrospectively followed for 12\u2009months. The primary endpoint was a composite of recurrence of venous thromboembolism (VTE), major bleeding event, or all\u2010cause mortality. The Cox regression model was used to compare the outcome of the two groups. The baseline mean (standard deviation) age of the patients was 48.4 (15.0) and 140 (69.7%) of them were female. 41.3% of the participants had one or more comorbidities, and the most common types of cancer were gynecologic (28.9%), hematologic (21.4%), and intra\u2010abdominal (16.9%). The most common type of thrombosis was deep vein thrombosis (DVT) (77.1%). The primary composite outcome of VTE recurrence, major bleeding event, and all\u2010cause mortality occurred in 25 (24.3%) patients in the warfarin group and 11 (11.2%) in the rivaroxaban group (hazard ratio (HR), 0.48; 95% confidence interval (CI), 0.24\u20130.97; <jats:italic>p<\/jats:italic>\u2009=\u20090.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rivaroxaban was found to be more efficacious and safer than warfarin for patients with CAT in a resource\u2010limited setting. This finding is congruent with reports from resource\u2010abundant countries and recommendations from major international societies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70105","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T12:18:52Z","timestamp":1737634732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing the Comparative Efficacy and Safety of Warfarin and Rivaroxaban for Cancer Associated Thrombosis: Experience From a Resource Limited Setting"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6923-1753","authenticated-orcid":false,"given":"Abel Tenaw","family":"Tasamma","sequence":"first","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9874-0390","authenticated-orcid":false,"given":"Tsegab Alemayehu","family":"Bukate","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahim","family":"Mehadi","sequence":"additional","affiliation":[{"name":"John H. Stroger Jr. Hospital of Cook County  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bereket Tagesse","family":"Handiso","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beniam Yohannes","family":"Kassa","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Omer","family":"Hassen","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekarias Seifu","family":"Ayalew","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawit Habtie","family":"Tegegne","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebeyehu Tessema","family":"Azibte","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tigest Abebaw","family":"Zewdie","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinsaye Zergaw","family":"Shihur","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonas Degelo","family":"Geremamo","sequence":"additional","affiliation":[{"name":"School of Medicine; College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeabsira Dessalegne","family":"Mesfin","sequence":"additional","affiliation":[{"name":"School of Medicine; 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