{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:35Z","timestamp":1753868675320,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>With the use of immune checkpoint inhibitors (ICIs) and targeted therapies, the clinical outcomes of metastatic melanoma have drastically improved. The current scenario has reduced the use of chemotherapy as a first\u2010line treatment. We report an interesting case of a patient with stage IV ano\u2010rectal canal malignant melanoma with an exceptional response to single\u2010agent temozolomide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>We diagnosed a 55\u2010year\u2010old female with stage IV anorectal melanoma, BRAF V600 mutation negative. Owing to her poor performance status (PS) and non\u2010affordability of immunotherapy, after informed decision\u2010making, she was started on single agent, temozolomide. She achieved a complete metabolic response and sustained it for 3\u2009years and continues to do so with the first\u2010line single\u2010agent temozolomide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a resource\u2010limited setting, where access to ICIs and targeted therapies is not feasible, and in patients who fail to tolerate these therapies, oral chemotherapy continues to remain effective and is worth trying in patients with poor PS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70121","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T11:52:31Z","timestamp":1736855551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged Remission in Metastatic Ano\u2010Rectal Malignant Melanoma With Single Agent Temozolomide"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9380-5144","authenticated-orcid":false,"given":"Anusha Mruthyunjaya","family":"Swamy","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Hematology All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-7694","authenticated-orcid":false,"given":"Deepak","family":"Sundriyal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-0044","authenticated-orcid":false,"given":"Mayank","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology All India Institute of Medical Sciences  Rishikesh Uttarakhand 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