{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:42Z","timestamp":1753868682140,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202934"],"award-info":[{"award-number":["82202934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M710752"],"award-info":[{"award-number":["2022M710752"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal management strategy for Stage IV rectal cancer with potentially treatable liver metastases remains controversial, particularly regarding the role of pelvic radiotherapy (RT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We intend to investigate the impact of pelvic RT on oncological outcomes of rectal cancer with potentially treatable liver metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This retrospective study included 83 patients diagnosed with rectal cancer and synchronous liver metastases from June 2012 to January 2022. All patients underwent radical surgery for rectal cancer and treatment of synchronous liver metastases, as determined by a multidisciplinary team (MDT). We divided the 83 patients into two treatment groups: chemoradiotherapy and surgery (CRT\u2009+\u2009S) and chemotherapy and surgery (C\u2009+\u2009S). The CRT\u2009+\u2009S group (<jats:italic>n<\/jats:italic>\u2009=\u200940) received pelvic RT, systemic therapy, and liver metastasis treatment. The C\u2009+\u2009S group (<jats:italic>n<\/jats:italic>\u2009=\u200943) received systemic therapy and liver metastasis treatment only. A total of 83 patients were analyzed with a median follow\u2010up of 45\u2009months (range 12\u2013127\u2009months). In the CRT\u2009+\u2009S group, 48.2% (40\/83) of patients underwent chemoradiotherapy, while the C\u2009+\u2009S group comprised 51.8% (43\/83) of patients who received chemotherapy only. The CRT\u2009+\u2009S group demonstrated significantly longer local recurrence\u2010free survival compared to the C\u2009+\u2009S group (median 37.5 vs. 34\u2009months; <jats:italic>p<\/jats:italic>\u2009=\u20090.011). In addition, patients in the CRT\u2009+\u2009S group had a longer median overall survival (OS) compared to the C\u2009+\u2009S group (46.50 vs. 44.0\u2009months; <jats:italic>p<\/jats:italic>\u2009=\u20090.0497). Notably, achieving no evidence of disease (NED) status after definitive treatment for both primary and liver metastases was associated with improved OS (<jats:italic>p<\/jats:italic>\u2009=\u20090.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that the addition of pelvic RT to multimodality therapy for patients with rectal cancer and potentially treatable liver metastases may improve local control and long\u2010term survival. The findings support the consideration of RT in the clinical management of this patient population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70122","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:37:09Z","timestamp":1737628629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pelvic Radiotherapy in Rectal Cancer Patients With Synchronous Potentially Treatable Liver Metastases"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9758-901X","authenticated-orcid":false,"given":"Yayu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Zhongshan Hospital (Xiamen), Fudan University  Xiamen China"},{"name":"Xiamen Clinical Research Center for Cancer Therapy  Xiamen China"},{"name":"Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province  Xiamen 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