{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:42Z","timestamp":1753868682142,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T00:00:00Z","timestamp":1738454400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K14496"],"award-info":[{"award-number":["JP23K14496"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liposarcoma and lymphoma are very rare tumors, and their combination is extremely rare. Moreover, there have been no reports of liposarcoma and lymphoma occurring in the same region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 58\u2010year\u2010old man presented to Kanagawa Cancer Center with a mass in his left thigh and underwent a needle biopsy. Histological analysis showed an increase in the number of small lymphocytes and plasma cells; immunohistochemical analysis showed an increase in CD20\u2010positive cells with Lambda light\u2010chain restriction; therefore, the diagnosis of B\u2010cell malignancy with plasma cell differentiation was made. A bone marrow biopsy specimen showed infiltration of atypical cells of the same phenotype and increased serum IgM\u2010M levels; therefore, a diagnosis of Waldenstr\u00f6m macroglobulinemia\/lymphoplasmacytic lymphoma (LPL) was made. The needle biopsy specimen showed scattered CDK4\u2010positive cells in the background of the lymphoma cells and sporadic <jats:italic>MDM2<\/jats:italic> signal amplification on fluorescence in\u00a0situ hybridization, suggesting mixed well\u2010differentiated liposarcoma (WDL). Tumor resection was performed. The tumor contained a mixture of WDL and LPL areas. RNA sequencing revealed upregulated expression of chemokine genes, including <jats:italic>CCL5<\/jats:italic>, <jats:italic>CCL18<\/jats:italic>, and <jats:italic>CCL19<\/jats:italic>, in WDL and that of the corresponding chemokine receptor genes <jats:italic>CCR4<\/jats:italic>, <jats:italic>CCR6<\/jats:italic>, and <jats:italic>CCR7<\/jats:italic> in the lymphoma cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemokine\u2013chemokine receptor axes may be involved in the pathogenesis of LPL cell\u2010infiltrating WDL. This is an extremely rare case, and we have reported some considerations regarding the tumorigenesis of LPL cell\u2010infiltrating WDL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70129","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T03:54:21Z","timestamp":1738554861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemokine Expression in Well\u2010Differentiated Liposarcoma May Be Involved in the Tumorigenesis of Lymphoplasmacytic Lymphoma: A Case Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-776X","authenticated-orcid":false,"given":"Kota","family":"Washimi","sequence":"first","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Kasajima","sequence":"additional","affiliation":[{"name":"Molecular Pathology and Genetics Division Kanagawa Cancer Center Research Institute  Yokohama Japan"},{"name":"Division of Health Medical Intelligence, Human Genome Center Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Advanced Cancer Therapeutics Kanagawa Cancer Center Research Institute  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Nezu","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Tumor Surgery Yokohama City University  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-9063","authenticated-orcid":false,"given":"Hiroyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Shizuoka Medical Center  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotoe","family":"Katayama","sequence":"additional","affiliation":[{"name":"Laboratory of Sequence Analysis, Human Genome Center Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Imoto","sequence":"additional","affiliation":[{"name":"Division of Health Medical Intelligence, Human Genome Center Institute of Medical Science, The University of Tokyo  Tokyo Japan"},{"name":"Laboratory of Sequence Analysis, Human Genome Center Institute of Medical Science, The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yokose","sequence":"additional","affiliation":[{"name":"Department of Pathology Odawara Municipal Hospital  Odawara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cancer Center  Yokohama Japan"},{"name":"Molecular Pathology and Genetics Division Kanagawa Cancer Center Research Institute  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,2]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"36","volume-title":"Soft Tissue and Bone Tumours. 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