{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:35:43Z","timestamp":1785522943008,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatocellular carcinoma (HCC) remains a significant global health burden, with unmet clinical needs despite the availability of multiple therapeutic options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present the case of an 85\u2010year\u2010old male diagnosed with HCC and bilateral lung metastases following hepatectomy. The patient responded favorably to treatment with icaritin and thalidomide, which resulted in a reduction in alpha\u2010fetoprotein (AFP) levels and tumor size. This treatment achieved partial remission, with a progression\u2010free survival (PFS) of 24\u2009months and an overall survival (OS) of 33\u2009months. Unfortunately, the patient ultimately passed away due to a cerebral infarction unrelated to cancer progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case underscores the potential of icaritin as a therapeutic option for HCC patients with compromised health status. The combination of icaritin and thalidomide demonstrated promising efficacy in this real\u2010world scenario. Multidisciplinary combination treatment strategies incorporating icaritin merit further exploration, given its immunomodulatory effects and favorable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70136","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:05:42Z","timestamp":1741727142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First\u2010Line Treatment of Icaritin and Thalidomide in a Patient With Hepatocellular Carcinoma With <scp>PR<\/scp>: A Case Report"],"prefix":"10.1002","volume":"8","author":[{"given":"Zaiyong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Hepatological Surgery Jilin City Central Hospital  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical Image Central, Jilin City Central Hospital  Jilin 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