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This review study was conducted to explore the influence of CA\u2010125 in addressing ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate the role of CA\u2010125 in ovarian cancer, we conducted a comprehensive search for high\u2010quality articles in the Medline, Web of Science Core Collection and Scopus databases using the keywords \u201covarian cancer,\u201d \u201covarian carcinoma,\u201d \u201covarian neoplasms,\u201d and \u201cCA\u2010125\u201d from the 2000 to 2024. We included full\u2010text, peer\u2010reviewed articles in English with relevant keywords published since 2000. We excluded case reports, commentaries, letters to the editor, books, case series, systematic reviews, animal studies, and articles that were not accessible in full text.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening the 7947 records, 88 studies were included in this review. In the literature review, it was found that researchers utilized CA\u2010125 for diagnosing ovarian cancer, its predicting, evaluating treatment response, assessing ovarian cancer survival, and early detection of recurrence. In some cases, researchers employed additional tumor markers alongside CA\u2010125 to enhance the test's sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CA\u2010125 has become a pivotal marker for ovarian cancer. Its role in the diagnosis, treatment, and ongoing assessment of ovarian cancer cannot be overstated. Continuous monitoring of CA\u2010125 levels can provide comprehensive insights, and categorizing patients as low\u2010risk or high\u2010risk based on CA\u2010125 levels could lead to better outcomes. Integrating CA\u2010125 with other biomarkers may enhance the accuracy of the test and elevate its relevance in patient care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70142","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:16:09Z","timestamp":1741742169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Role of <scp>CA<\/scp>\u2010125 in the Management of Ovarian Cancer: A Systematic Review"],"prefix":"10.1002","volume":"8","author":[{"given":"Zohre","family":"Momenimovahed","sequence":"first","affiliation":[{"name":"Reproductive Health Department Qom University of Medical Sciences  Qom Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrooz","family":"Mazidimoradi","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Allahqoli","sequence":"additional","affiliation":[{"name":"Midwifery Department Ministry of Health and Medical Education  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7642-5214","authenticated-orcid":false,"given":"Hamid","family":"Salehiniya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health, Social Determinants of Health Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/oncologie\u20102023\u20100172"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092230"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1792948"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S197604"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20126089"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191912057"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_9_9_1","series-title":"Seminars in Oncology Nursing","volume-title":"Ovarian Cancer: An Integrated Review","author":"Stewart C.","year":"2019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes10020016"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009623666230209121732"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics7010014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes12010008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188503"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003295"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606092"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"issue":"2","key":"e_1_2_9_18_1","first-page":"84","article-title":"Tumor Marker CA\u2010125 as an Evaluator and Response Indicator in Ovarian Cancer: Its Quantitative Correlation With Tumor Volume","volume":"11","author":"Kumar P.","year":"2005","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.75"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655102317475434"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.12.025"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182681cfd"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.04.030"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15492"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.15_suppl.e16546"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1724600820955195"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12799"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.15296\/ijwhr.2022.28"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.02.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2204993"},{"issue":"3","key":"e_1_2_9_31_1","first-page":"361","article-title":"Epithelial Ovarian Cancer: Role of Pegylated Liposomal Doxorubicin in Prolonging the Platinum\u2010Free Interval and Cancer Antigen 125 Trends During Treatment","volume":"19","author":"Tanguay J. 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