{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:25:33Z","timestamp":1787509533513,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pre\u2010operative very low calorie diets (VLCDs) can achieve rapid and safe weight loss, yet no studies have evaluated VLCDs in the severely obese endometrial cancer population prior to surgery. Our aim was to evaluate the safety and feasibility of a 4\u20136\u2009week pre\u2010operative nutritional intervention with the Optifast VLCD prior to surgery in patients with clinical stage 1, Grade 1 endometrioid endometrial adenocarcinoma and a body mass index \u2265\u200935\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an investigator\u2010initiated single\u2010arm prospective observational study. Co\u2010primary endpoints were safety and feasibility. Secondary endpoints were changes in anthropometric measures, blood pressure, biochemistry, perioperative complications, length of stay and final tumour stage. Tolerability and compliance of the VLCD were assessed by fortnightly questionnaires and urinary ketones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010eight patients were enrolled, of which 25 underwent the intervention. 22\/25 patients (88%) completed at least 4\u2009weeks of Optifast. Mean (SD) age was 56.4 (6.3) years, and mean body mass index (BMI) was 45.2 (7.1) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Significant decreases in weight (mean 8.2\u2009kg [3.6]), BMI (mean 3.1\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      [1.3]), waist and hip circumference (mean 5.7 [6.5] and 4.5\u2009cm [4.1], respectively), and diastolic blood pressure (10\u2009mmHg [14.1]) were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all). One patient had a flare of gout. All patients had laparoscopic surgery without adverse events. Optifast was considered acceptable, and compliance was 40% to 61.9%. Eighty\u2010eight percent (22\/25) of patients had FIGO 2009 Stage 1A Grade 1 endometrioid endometrial adenocarcinoma on final staging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 4\u20136\u2009week pre\u2010operative VLCD in severely obese clinically low\u2010risk endometrial cancer patients appears safe, feasible and well tolerated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70172","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T15:40:39Z","timestamp":1743781239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Single Arm Pilot Observational Study to Evaluate the Safety and Feasibility of a Pre\u2010Operative Very Low Calorie Diet in Severely Obese Patients With Endometrial Cancer"],"prefix":"10.1002","volume":"8","author":[{"given":"Chloe","family":"Ayres","sequence":"first","affiliation":[{"name":"Western Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital  Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Burbidge","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Women and Newborn Health Service, King Edward Memorial Hospital  Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayna","family":"Garratt","sequence":"additional","affiliation":[{"name":"Western Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital  Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganendra Raj","family":"Mohan","sequence":"additional","affiliation":[{"name":"Western Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital  Subiaco Western Australia Australia"},{"name":"Department of Gynaecological Oncology St John of God Subiaco Hospital  Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee","family":"Leung","sequence":"additional","affiliation":[{"name":"Western Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital  Subiaco Western Australia Australia"},{"name":"Division of Obstetrics and Gynaecology Medical School, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Jeffares","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology St John of God Subiaco Hospital  Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanela","family":"Bilic","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology St John of God Subiaco Hospital  Subiaco Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-9232","authenticated-orcid":false,"given":"Paul A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Western Australian Gynaecologic Cancer Service, Department of Obstetrics and Gynaecology, Women and Newborn Health Service, King Edward Memorial Hospital  Subiaco Western Australia Australia"},{"name":"Division of Obstetrics and Gynaecology Medical School, University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081907"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.273"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000278"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12819"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-020-05070-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2017.09.531"},{"key":"e_1_2_13_8_1","unstructured":"Australia Institute of Health and Welfare \u201cCancer in Australia 2021. 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