{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:28:09Z","timestamp":1769052489947,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>Background<\/jats:title>Intraductal papillomas of the breast (IDPs) are typically small benign lesions characterized by pathologic discharge, a palpable mass, or an occult presentation. Giant IDPs (>\u20095\u2009cm) are a rare entity. The few existing cases of giant IDPs describe grossly apparent exam findings and concerning features on imaging. While surgical excision is the standard of care for most IDPs, there is a scarcity of evidence to guide management of giant papillary tumors.<\/jats:p><\/jats:sec>Case<\/jats:title>We describe a case of a 64\u2010year\u2010old female presenting with pathologic nipple discharge and no discrete palpable breast mass who was routinely diagnosed with ductal carcinoma in\u00a0situ (DCIS). Imaging findings of mass calcifications and intraductal mass debris correlated with biopsy results, and the patient underwent central lumpectomy with oncoplastic reconstruction. At the time of surgery, the DCIS was incidentally found to be contained within a large solitary papilloma. The specimen pathology showed DCIS spanning a large area in a multifocal pattern that involved a 7\u2009cm giant intraductal papilloma. Though margins were negative for malignancy, the benign papillary lesion was incompletely excised. A multidisciplinary review opted to pursue whole breast radiation therapy followed by adjuvant endocrine treatment over re\u2010excision.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This unusual case highlights the potential for giant IDP to remain clinically occult in the background of known ductal carcinoma in\u00a0situ and emphasizes the value of multidisciplinary care discussion and a patient\u2010centered approach to surgical decision making in the absence of existing guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70184","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:16:03Z","timestamp":1742361363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case of Incidental Giant Intraductal Papilloma Containing Ductal Carcinoma In\u00a0Situ"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8383-065X","authenticated-orcid":false,"given":"Micaela","family":"Resta","sequence":"first","affiliation":[{"name":"University of New Mexico School of Medicine Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Surgery University of New Mexico Health Sciences Center Albuquerque New Mexico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"225","article-title":"Papillary Lesions of Breast","volume":"111","author":"Karadeniz E.","year":"2016","journal-title":"Chirurgia"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.11.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.116"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"60","article-title":"Case of the Month. Giant Multiple Intraductal Papilloma of the Breast: A Case Report and Review of the Literature","volume":"60","author":"Kavolius J.","year":"2001","journal-title":"Hawaii Medical Journal"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1136"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282\u2010008\u20100092\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930280409"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806\u20109282.60.06.007"},{"key":"e_1_2_10_10_1","unstructured":"National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer V.6.2024accessed January 6 2025 available athttp:\/\/NCCN.org."},{"key":"e_1_2_10_11_1","volume-title":"PDQ Breast Cancer Treatment","author":"PDQ Adult Treatment Editorial Board","year":"2002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.8575"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10396\u2010006\u20100128\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010020\u201000732\u20103"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010021\u201010188\u20107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2011.100434"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8507"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2421031988"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:24:25Z","timestamp":1748363065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cnr2.70184"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70184","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70184"}}