{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:07:35Z","timestamp":1780632455512,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thyroid Autoantibodies (TgAbs) are associated with autoimmune thyroid disorders and are also used in thyroid cancer follow\u2010up to monitor for recurrence of disease. This study aimed to explore the potential utility of TgAbs as a surrogate tumor marker and examine the relationship between fluctuations in TgAbs levels and disease recurrence in patients with Differentiated Thyroid Cancer (DTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cohort study was conducted on a sample of 97 patients who underwent thyroidectomy for differentiated thyroid cancer (DTC) between the years 2017 and 2021. Following surgery (with or without lymph node dissection), levothyroxine therapy and 131 iodine were prescribed (as necessary). Regular laboratory evaluations were conducted, which involved measuring Tg and TgAb at 3 and 6\u2009months postoperatively. Patients were classified based on recurrence rate and different levels of TgAb, and ROC analysis was applied. All data were analyzed with SPSS24, and a\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;\u20090.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For low\u2010risk patients, TgAb trends over time showed an increase at 6\u2009months, while for high\u2010risk patients, TgAb levels continuously rose starting from 3\u2009months. Although TgAb levels above the functional sensitivity threshold did not predict recurrence overall, changes in TgAb levels at 6\u2009months compared to 3\u2009months after surgery were indicative of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the entire population, having TgAb levels higher than the functional sensitivity threshold had no risk of various relapses. However, changes in TgAb serum levels at 6\u2009months after surgery, compared to 3\u2009months after surgery, can serve as an indication of tumor recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70191","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T10:49:56Z","timestamp":1748342996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Relationship Between Serum Levels of Thyroglobulin Antibody and the Risk of Recurrence in Patients With Differentiated Thyroid Cancer"],"prefix":"10.1002","volume":"8","author":[{"given":"Amirian","family":"Fatemeh","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaghoubi","family":"Mohammad Ali","sequence":"additional","affiliation":[{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8745-6558","authenticated-orcid":false,"given":"Mehrad\u2010Majd","family":"Hassan","sequence":"additional","affiliation":[{"name":"Cancer Molecular Pathology Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Clinical Research Development Unit Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohebbi","family":"Masoud","sequence":"additional","affiliation":[{"name":"Endocrine Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layegh","family":"Parvin","sequence":"additional","affiliation":[{"name":"Endocrinology &amp; Metabolism Member of Metabolic Syndrome Research Center (MSRC) Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vazifeh\u2010Mostaan","family":"Leila","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadgar Moghaddam","family":"Maliheh","sequence":"additional","affiliation":[{"name":"Community Medicine, Community Medicine Department School of Medicine  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7930-0764","authenticated-orcid":false,"given":"Amirian","family":"Zahra","sequence":"additional","affiliation":[{"name":"University of Medicine, Trauma and General Surgery Wards, Imam Ali Hospital  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4821-9516","authenticated-orcid":false,"given":"Taghavi","family":"Ghazaleh","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1604412"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0606"},{"key":"e_1_2_12_5_1","first-page":"3","article-title":"Guidelines for the Diagnosis and Management of Thyroid Nodules","volume":"1","author":"Gharib M.","year":"2011","journal-title":"Thyroid 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H.","year":"2023","journal-title":"Archives of Endocrinology and Metabolism"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0962"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0621"},{"issue":"1","key":"e_1_2_12_18_1","first-page":"49","article-title":"The Prevalence of Pre\u2010Thyroidectomy Thyroid Function Test Abnormalities Among Patients With Differentiated Thyroid Carcinoma: A Descriptive Study","volume":"31","author":"Barashki S.","year":"2023","journal-title":"Iranian Journal of Nuclear Medicine"},{"key":"e_1_2_12_19_1","unstructured":"C.Latour \u201cThe Relationship Between Thyroglobulin Antibodies (TgAb) and Differentiated Thyroid Cancer (DTC) Recurrence After Total Thyroidectomy and Radioactive Iodine Treatment\u201d(2023)."},{"issue":"1","key":"e_1_2_12_20_1","first-page":"29","article-title":"The Relationship Between Pre\u2010Operative Anti\u2010Thyroglobulin Antibody Level and Lymph Node Metastasis and Recurrence in Differentiated Thyroid Cancer","volume":"38","author":"Kaynak H.","year":"2023","journal-title":"Turkish Journal of Oncology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-022-03283-6"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01940"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_340_17"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20101967"}],"container-title":["Cancer 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