{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:35:44Z","timestamp":1784892944542,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elesclomol (ES) is a promising anticancer compound that exerts its effects through multiple mechanisms. It acts as a copper (Cu(II)) ionophore, forming an ES\u2013Cu complex within cancer cells and inducing a novel form of cell death called cuproptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To provide an up\u2010to\u2010date review on elesclomol and its nano\u2010formulations with a particular focus on cancer therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Sources<\/jats:title><jats:p>Literature was collected by manually searching in Pubmed, and Google Scholar, clinicaltrials.gov through March 2025.<\/jats:p><\/jats:sec><jats:sec><jats:title>Content<\/jats:title><jats:p>This review provides an overview of the discovery and development of the ES molecule, including its physicochemical properties. New insights into the intracellular interactions of ES with copper and the mechanisms of copper transportation are then explained. The recent clinical outcomes of ES in cancer therapy, both as a monotherapy and in combination with paclitaxel or carboplatin, are summarized. While the initial clinical trials showed promise, more studies are focusing on the preclinical investigations of the ES\u2013Cu complex. Nanomedicine\u2010based formulations have emerged as a strategy to enhance the intracellular delivery of ES as well as its therapeutic effects, with several ES\u2013Cu nanomedicines currently under development. The recent nanoparticle delivery strategies of ES are discussed. This comprehensive review provides an up\u2010to\u2010date overview of the recent advancements in ES study, including its novel mechanism of action, clinical progress, and the potential of nanomedicine\u2010based approaches to improve its therapeutic efficacy in cancer treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70193","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T08:07:56Z","timestamp":1744099676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An up\u2010To\u2010Date Review of Elesclomol and Its Nano\u2010Formulations in Cancer Therapy"],"prefix":"10.1002","volume":"8","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Drug Discovery and Development Harrison College of Pharmacy  Auburn Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute on Drug Abuse, National Institutes of Health  North Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-7155","authenticated-orcid":false,"given":"Amit K.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, University of Arkansas of Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-2291","authenticated-orcid":false,"given":"R. 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