{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:05:17Z","timestamp":1791255917560,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis when treated using conventional chemotherapy. CPX\u2010351, a liposomal formulation of cytarabine and daunorubicin, has demonstrated potential as a novel therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review aims to evaluate the clinical safety and efficacy of CPX\u2010351 compared to standard induction chemotherapy in patients with AML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted using Web of Science, PubMed, Google Scholar, Ovid MEDLINE, and the Cochrane Library from 2011 to 2023. Overall, 14 clinical trials with more than 800 AML patients were included. Data on adverse events, survival outcomes, and response rates were extracted and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CPX\u2010351 exhibited an adverse event profile that was comparable to that of conventional chemotherapy. It resulted in complete remission rates of 18%\u201341% in relapsed\/refractory AML patients. For newly diagnosed individuals, CPX\u2010351 led to complete remission rates of 41%\u201358%, surpassing the 14%\u201340% associated with standard chemotherapy. Additionally, it extended overall survival by 3.6\u20135.7\u2009months, with significant advantages noted in high\u2010risk cytogenetics and secondary AML cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review presents strong evidence supporting CPX\u2010351 as a therapeutic alternative with superior efficacy and comparable safety to standard chemotherapy across diverse AML populations. This represents a breakthrough in therapy, with demonstrated efficacy in AML cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70199","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T07:44:43Z","timestamp":1746776683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Clinical Safety and Efficacy of Cytarabine and Daunorubicin Liposome (\n                    <scp>CPX<\/scp>\n                    \u2010351) in Acute Myeloid Leukemia Patients: A Systematic Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6553-7123","authenticated-orcid":false,"given":"Abdulwahab M.","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Al Baha Health Cluster Ministry of Health  Al Baha Saudi Arabia"},{"name":"Pharmaceutical Practices Department College of Pharmacy, Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-5437","authenticated-orcid":false,"given":"Mohammed A.","family":"Alnuhait","sequence":"additional","affiliation":[{"name":"Pharmaceutical Practices Department College of Pharmacy, Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1094-6835","authenticated-orcid":false,"given":"Tariq","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.10"},{"key":"e_1_2_13_3_1","volume-title":"StatPearls [Internet]","author":"Chennamadhavuni A.","year":"2023"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00553"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6112"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2na00483f"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/PBC.25133"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11080845"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.284109.116"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v100.4.1224.h81602001224_1224_1232"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.056390"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1391216"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2022.02.008"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.01.015"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201040218\u20100"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S139450"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14122843"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S141212"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3909"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1725503"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010022\u201001361\u2010w"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201012\u2010540971"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28974"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201018\u20102990"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.182642"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1688320"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010020\u20100916\u20108"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003510"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010276"},{"key":"e_1_2_13_30_1","first-page":"1","article-title":"Cochrane; ROBINS\u2010I_Detailed_Guidance","volume":"366","author":"Sterne J. 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