{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:44:42Z","timestamp":1753868682344,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Small bowel adenocarcinomas (SBAs) are rare and aggressive cancers. About one\u2010fifth of SBA patients have predisposing conditions; among them, there are also genetic tumor syndromes, including Lynch syndrome, familial adenomatous polyposis, and Peutz\u2010Jeghers syndrome. Although <jats:italic>BRCA2<\/jats:italic> mutations, both somatic and germline, have been recently described in SBAs, direct evidence of <jats:italic>BRCA2<\/jats:italic> inactivation in SBA tumor tissue of patients with <jats:italic>BRCA2<\/jats:italic>\u2010related hereditary cancer syndrome is still very limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Herein, we described a case of a 51\u2010year\u2010old woman with a history of breast cancer who developed an adenocarcinoma of the duodeno\u2010jejunal flexure causing persistent vomiting. After clinical staging, the patient underwent surgical resection, and histologic examination of the specimen confirmed a poorly differentiated adenocarcinoma infiltrating the visceral peritoneum and showing lymph node metastases (stage III, pT4N1). Two years later, the SBA relapsed, and next generation sequencing was performed in matched tumor and normal tissues. In addition to <jats:italic>KRAS<\/jats:italic> and <jats:italic>TP53<\/jats:italic> mutations in the tumor, both somatic and germline <jats:italic>BRCA2<\/jats:italic> mutations were identified, indicating biallelic <jats:italic>BRCA2<\/jats:italic> alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>BRCA2<\/jats:italic>\u2010associated hereditary tumor syndrome could have an etio\u2010pathogenetic role in SBA development; thus, we suggest that this syndrome should be considered in patients with an SBA diagnosis below the age of 50\u2009years, especially when a personal or family history of breast cancer is present.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70200","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:12:16Z","timestamp":1744258336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>BRCA2<\/i>\u2010Related Hereditary Cancer Syndrome\u2010Associated Small Bowel Adenocarcinoma With Multiple <i>BRCA2<\/i> Mutations: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"8","author":[{"given":"Francesca","family":"Antoci","sequence":"first","affiliation":[{"name":"Anatomic Pathology Unit IRCCS San Matteo Hospital Foundation  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Colella","sequence":"additional","affiliation":[{"name":"University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Biletta","sequence":"additional","affiliation":[{"name":"Unit of Pathology, Department of Surgery ASL BI Nuovo Ospedale Degli Infermi  Ponderano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit IRCCS San Matteo Hospital Foundation  Pavia 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