{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:11:50Z","timestamp":1773007910162,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802576"],"award-info":[{"award-number":["81802576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While there is a growing volume of evidence suggesting that relatively prevalent functional polymorphisms present within apoptosis\u2010related genes may influence human prostate cancer (PCa) susceptibility, the clinical relevance of these findings remains inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This meta\u2010analysis was thus developed with the goal of generating more precise estimates of the relationships between polymorphisms in four apoptosis\u2010associated genes (NKX3\u20101, caspase\u20103, caspase\u20109, and BCL\u20102) and the risk of PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      The PubMed, Web of Science, Google Scholar, Embase, Cochrane Library, and SinoMed (CNKI and Wanfang) databases were searched for relevant studies published through December 20, 2023, using the following keywords: \u201cpolymorphism\u201d or \u201cvariant\u201d and \u201ccarcinoma\u201d or \u201ccancer\u201d or \u201ctumor\u201d and \u201cNKX3\u20101,\u201d \u201cCASP3\u201d or \u201cCaspase\u20103,\u201d \u201cCASP9\u201d or \u201cCaspase\u20109,\u201d \u201cBCL\u20102\u201d or \u201cB\u2010cell lymphoma\u201d and \u201cprostate cancer\u201d or \u201cPCa\u201d or \u201cprostate adenocarcinoma.\u201d This approach led to the identification of 22 case\u2013control studies related to the association between apoptosis\u2010related gene polymorphisms and PCa susceptibility enrolling 9706 cases and 12\u2009567 controls. Subsequent analyses revealed that the\n                      <jats:italic>NKX3\u20101<\/jats:italic>\n                      rs2228013,\n                      <jats:italic>CASP9<\/jats:italic>\n                      rs1052571, and\n                      <jats:italic>CASP9<\/jats:italic>\n                      rs4645982 polymorphisms were associated with greater PCa risk, whereas the\n                      <jats:italic>CASP3<\/jats:italic>\n                      rs4647603 polymorphism was associated with a risk reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide strong evidence for the potential contributions of polymorphisms in the apoptosis\u2010related caspase\u20103, caspase\u20109, and NKX3\u20101 genes in the onset and progression of PCa.<\/jats:p>\n                  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