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With advances in cancer treatment, widespread use of immunotherapy, and prolonged survival of cancer patients, the coexistence of tuberculosis (TB) and cancer is becoming increasingly common in clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This review aims to explore the interaction between tuberculosis (TB) and tumors, particularly lung cancer (LC), and to identify appropriate clinical management approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LC patients with a history of TB have higher adjusted risk ratios for both all\u2010cause and cancer\u2010specific 3\u2010year mortality compared to those without a history of TB. TB may elevate the risk of developing tumors through mechanisms such as chronic inflammation, altered immune responses, and DNA damage. Conversely, cancer patients, whether due to the disease itself or immune dysfunction caused by anti\u2010tumor treatments, may be more susceptible to TB. The coexistence of TB and tumors presents significant challenges in clinical management, making the development of treatment strategies and quality\u2010of\u2010life improvements crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a close relationship between TB and cancer, with TB potentially serving as a risk factor for cancer, and cancer influencing susceptibility to TB. Effective clinical management is essential to enhance treatment strategies and improve the quality of life for patients with both TB and cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70213","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:46:59Z","timestamp":1747190819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Coexisting Lung Cancer and Pulmonary Tuberculosis: A Comprehensive Review From Incidence to Management"],"prefix":"10.1002","volume":"8","author":[{"given":"Wendi","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis Research, Guangzhou Chest Hospital, Institute of Tuberculosis Guangzhou Medical University  Guangzhou P. R. 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