{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:11:39Z","timestamp":1773007899250,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melanoma of the oral mucosa is an uncommon cancer arising from the tissues lining the mouth. Among oronasal malignant melanomas, tongue melanoma makes up a mere 2%. Optimal treatments for this rare and often late\u2010stage disease remain elusive. However, surgery with free margins is considered the primary treatment and is often combined with other therapies such as neck dissection, adjuvant radiotherapy, chemotherapy, and immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>This case involves a 33\u2010year\u2010old woman with a history of malignant melanoma on her tongue. She had previously undergone a partial glossectomy and was on maintenance imatinib treatment for ~2\u2009years. During her follow\u2010up, a new lesion was discovered on her tongue, which was confirmed to be malignant melanoma and was resected. The tumor exhibited a depth of invasion of 8\u2009mm. All surgical margins were clear, with the closest margin being 3\u2009mm. The lesion was reconstructed with a submental flap. Adjuvant radiotherapy was also given. The patient has been on maintenance follow\u2010up for 3\u2009years with no signs of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Malignant melanoma should be considered in the differential diagnosis of pigmented and non\u2010pigmented lesions of the tongue and oral mucosa. A thorough clinical evaluation, followed by histopathological and immunohistochemical examination of any suspicious lesions, is essential for early diagnosis. Early detection and prompt treatment are crucial for optimizing patient outcomes and improving survival rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70215","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:55:23Z","timestamp":1746755723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Malignant Melanoma on the Tongue: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"8","author":[{"given":"Maziar","family":"Motiee\u2010Langroudi","sequence":"first","affiliation":[{"name":"Imam Khomeini Complex Hospital Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-2138","authenticated-orcid":false,"given":"Athena","family":"Farahzadi","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology Cancer Institute, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouyan","family":"Aminshakib","sequence":"additional","affiliation":[{"name":"Pathology Department Cancer Institute, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090965"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/975358"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/mmt\u20102018\u20100003"},{"issue":"6","key":"e_1_2_11_5_1","first-page":"E309\u201311","article-title":"Primary Malignant Melanoma of the Tongue","volume":"52","author":"Khalifa H.","year":"2009","journal-title":"Canadian Journal of Surgery"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_236_18"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.09.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u2010029X.110699"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2017.11.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.01.026"},{"key":"e_1_2_11_11_1","volume-title":"Oral Malignant Melanoma","author":"Collins B.","year":"2010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5935\/2525\u20105711.20170041"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010015\u20101459\u20103"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"120","article-title":"Malignant Melanoma: A Case Report With Literature Review","volume":"7","author":"Gadodia P.","year":"2016","journal-title":"New Jersey Institute of Technology Research and Innovation Magazine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00320-2"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1051\/mbcb\/2019003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-012-0311-3"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197408)34:2<358::AID-CNCR2820340221>3.0.CO;2-D"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010021\u201001366\u2010w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2023.09.002"},{"key":"e_1_2_11_21_1","volume-title":"Cancer Staging Manual","author":"American Joint Committee on Cancer","year":"2023"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco\u201023\u201016"},{"key":"e_1_2_11_23_1","volume-title":"Mucosal Melanoma of the Head and Neck: From Diagnosis to Treatment","author":"Bezerra Toscano Mendon\u00e7a U.","year":"2021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.299"},{"key":"e_1_2_11_25_1","volume-title":"Oral Melanoma","author":"Zito P. 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