{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:11:17Z","timestamp":1773007877123,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple myeloma is a malignant disorder involving the uncontrolled proliferation of plasma cells in the bone marrow. Prognosis remains poor for individuals with relapsed and refractory multiple myeloma (RRMM), and the underlying mechanisms are yet to be fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected bone marrow RNA\u2010Seq data from a total of 557 patients with MM from the GEO database (GSE24080) for further analysis, dividing them into relapsed\/refractory and control groups. Additionally, we collected bone marrow samples from 57\u2009MM patients to validate the performed RNA\u2010Seq data analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RNA\u2010Seq analysis of patients with RRMM revealed a significant upregulation of genes associated with cuproptosis. Using the LASSO Cox regression method, several long noncoding RNAs (lncRNAs) were identified that influence copper\u2010induced cell death. Based on these lncRNAs, patients were stratified into high\u2010risk and low\u2010risk groups. The high\u2010risk group exhibited a significantly worse overall survival (OS) compared to the low\u2010risk group, with a\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of less than 0.001. Our statistical analysis, incorporating LASSO Cox regression, indicated that among these lncRNAs, MAMDC2\u2010AS1 was particularly noteworthy due to its strong correlation with OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;\u20090.01). Further validation using qPCR and survival analysis established MAMDC2\u2010AS1 as a strong predictor of prognosis in MM. This finding suggests that MAMDC2\u2010AS1 can serve as a potential independent biomarker for RRMM. The qPCR data validated the RNA\u2010Seq findings and uncovered the significance of MAMDC2\u2010AS1 in the prognosis of this disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAMDC2\u2010AS1 plays a significant role in RRMM. Promisingly, Bortezomib, Bosutinib, Crizotinib, and DMOG have demonstrated promising efficacy in addressing advanced cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70216","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:46:13Z","timestamp":1746755173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MAMDC2<\/scp>\n                    \u2010\n                    <scp>AS1<\/scp>\n                    Induces Cuproptosis in Relapsed and Refractory Multiple Myeloma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-2654","authenticated-orcid":false,"given":"Yifei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology Jiangdu People's Hospital  Yangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangdu People's Hospital  Yangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangdu People's Hospital  Yangzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2586"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2016.11.004"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.08.019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-078022"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102284"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2406536"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0205"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70331"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2024.104266"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01200-w"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP-24-00752"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-024-01623-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1152223"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00315-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011723"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0374"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.04.003"},{"key":"e_1_2_12_21_1","first-page":"243","article-title":"Effect of Copper on Immune Function and Disease Resistance","volume":"258","author":"Stabel J. 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