{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:10:15Z","timestamp":1771326615071,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Imatinib treatment is approved for several indications, including chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Although adverse events are common, hypersensitivity reactions are not. Because there is a clear clinical benefit of imatinib treatment, re\u2010introduction of imatinib after a hypersensitivity reaction should be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>Here we present a case report of a 68\u2010year\u2010old patient with a GIST diagnosis who was re\u2010introduced to imatinib after a type IV hypersensitivity reaction via desensitization. A desensitization plan, a plan for formulation of low\u2010dose imatinib capsules, and the essential steps when considering desensitization are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our case of a patient with a type IV hypersensitivity reaction after starting imatinib treatment demonstrates that desensitization is a feasible option after serious cutaneous adverse events in specific cases, when done with good interdisciplinary collaboration and clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70238","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:44:30Z","timestamp":1749645870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Imatinib Desensitization After a Type\n                    <scp>IV<\/scp>\n                    Hypersensitivity Reaction in a Gastrointestinal Stromal Tumor Patient\u2014A Case Report"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8492-8039","authenticated-orcid":false,"given":"Maud B. A.","family":"van der Kleij","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Division of Medical Oncology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Medical Oncology Erasmus MC Cancer Institute, Erasmus University Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan V. M.","family":"Bruijn","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Dermatology Amsterdam University Medical Center, University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-3853","authenticated-orcid":false,"given":"Raween W.","family":"Kalicharan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Pharmacology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7148-2439","authenticated-orcid":false,"given":"Yannick S.","family":"Elshot","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Dermatology Amsterdam University Medical Center, University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime C. F.","family":"Pilon","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Oostdijk","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs M.","family":"Tibben","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Pharmacology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan","family":"Nuijen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Pharmacology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-4639","authenticated-orcid":false,"given":"Alwin D. R.","family":"Huitema","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Pharmacology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Clinical Pharmacy Utrecht University Medical Centre, Utrecht University  Utrecht the Netherlands"},{"name":"Department of Pharmacology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7580-0684","authenticated-orcid":false,"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology\u2010Allergology and Occupational Dermatology Amsterdam University Medical Centre  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-2279","authenticated-orcid":false,"given":"Neeltje","family":"Steeghs","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Division of Medical Oncology The Netherlands Cancer Institute, Antoni van Leeuwenhoek  Amsterdam the Netherlands"},{"name":"Department of Medical Oncology Utrecht University Medical Centre, Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.08.033"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2014.05.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.4818"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-023-01293-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0498"},{"key":"e_1_2_9_7_1","unstructured":"Committee for Medicinal Products for Human Use (CHMP) European Medicines Agency \u201cGlivec European Public Assessment Report 2009 \u201dhttps:\/\/www.ema.europa.eu\/en\/documents\/product\u2010information\/glivec\u2010epar\u2010product\u2010information_en.pdf."},{"key":"e_1_2_9_8_1","volume-title":"Type I Hypersensitivity Reaction","author":"Abbas M.","year":"2024"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60016-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-438"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0304"},{"issue":"5","key":"e_1_2_9_12_1","first-page":"345","article-title":"Successful Progressive Challenge After a Cutaneous Reaction to Imatinib Mesylate (Gleevec): A Case Report and Review of the Literature","volume":"25","author":"Park M. 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