{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:10:50Z","timestamp":1771326650485,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J011278"],"award-info":[{"award-number":["2021J011278"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Breast cancer ranks first in the global incidence rate of malignant tumors in women. Despite the continuous emergence of new treatment methods, it remains a significant threat to the lives and quality of life of patients. Insulinoma, a rare pancreatic neuroendocrine tumor, causes pancreatic beta cells to over\u2010secrete insulin, disrupting the normal physiological feedback mechanism and leading to hyperinsulinemia. Studies have demonstrated that hyperinsulinemia can promote tumor development through various pathways, posing substantial challenges to tumor treatment. However, in previous studies, no successful treatment cases of breast cancer combined with insulinoma have been reported. Therefore, we present a case of metastatic breast cancer co\u2010occurring with insulinoma. The patient presented with a rapidly growing mass in the left breast accompanied by recurrent hypoglycemic symptoms. Following our treatment, the condition was significantly and effectively controlled.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 57\u2010year\u2010old female with a rapidly enlarging mass in the left breast for over 1\u2009year, currently measuring approximately 11\u2009\u00d7\u200910\u2009\u00d7\u20098\u2009cm, with multiple enlarged and fused lymph nodes palpable in the ipsilateral axilla and bilateral neck. She had a history of recurrent hypoglycemic symptoms for 2\u2009years, confirmed by laboratory tests, imaging examinations, fine needle aspiration biopsy (FNA), as metastatic breast cancer combined with insulinoma. On August 3, 2023, she underwent ultrasound\u2010guided alcohol ablation of the insulinoma and complete neoadjuvant therapy for breast cancer. The hypoglycemic symptoms disappeared and the tumor was rapidly and effectively controlled. Unfortunately, due to economic reasons, the patient refused further surgical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The unique aspect of this case lies in the rapid growth of a breast mass over a one\u2010year period, accompanied by recurrent episodes of hypoglycemia. Following clinical evaluation, the diagnosis was metastatic breast cancer with concomitant insulinoma. To our knowledge, reports of similar cases are scarce. This case underscores the importance for clinicians to remain vigilant when encountering rapidly progressing cancers, particularly in identifying various factors that may contribute to cancer development. When multiple diseases coexist, it is crucial to recognize the interrelationships between these conditions and to adopt a multidisciplinary approach to treatment, thereby striving to provide the best personalized care for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70243","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T20:29:36Z","timestamp":1750710576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Development of Breast Mass With Recurrent Episodes of Hypoglycemia Should Raise Suspicion of Breast Cancer With Insulinoma: A Case Report"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7240-035X","authenticated-orcid":false,"given":"Tingting","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Surgery Fuzong Clinical Medical College of Fujian Medical University  Fuzhou China"},{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruohan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"},{"name":"Department of General Surgery Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqiu","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of General Surgery Fuzong Clinical Medical College of Fujian Medical University  Fuzhou China"},{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Fuzong Clinical Medical College of Fujian Medical University  Fuzhou China"},{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"},{"name":"Department of General Surgery Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery 900th Hospital of PLA Joint Logistic Support Force  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.21635"},{"key":"e_1_2_12_3_1","first-page":"58","volume-title":"Endotext","author":"Herder W. 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