{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:16:51Z","timestamp":1780697811049,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aseptic loosening from endoprosthetic reconstructions following bone tumour resection is a major issue, especially in the revision\/multiple revisions settings. The objective was to present long\u2010term outcomes of revision limb salvage surgery using a custom hydroxyapatite\u2010coated stem collar with an extracortical plate at the bone\u2010implant junction specifically designed to prevent aseptic loosening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen (15) patients with an initial extremity bone tumour resection and reconstruction who underwent revision surgery utilizing this implant specification between 2004 and 2016 were included. Multiple prior surgeries and short\u2010segment stem fixation (&lt;\u2009100\u2009mm) were observed in six and nine patients, respectively. Outcomes of interest were rates of aseptic loosening and radiographic evidence of osseointegration along with clinical and functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At mean 12\u2010year follow\u2010up (range 6.5 to 18), no patient had evidence of radiographic or clinical aseptic loosening. The distal femur location (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044), endoprosthetic reconstruction as index procedure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), mechanical failure as reason for revision (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0047) and additional fixation to the extracortical plate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041) were associated with higher bone ingrowth scores. All but two patients, who had mild pain only, were pain\u2010free. Joint range of motion (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and limb\u2010length discrepancy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) significantly improved. The mean Musculoskeletal Tumor Society score was 26.1 (excellent).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated excellent results in preventing long\u2010term aseptic loosening with this custom implant specification, which is useful particularly for revisions\/multiple revisions and short\u2010segment fixation. However, further larger scale and multicentric studies are needed to validate the data to the broader population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70254","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:59:32Z","timestamp":1750899572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Custom Hydroxyapatite\u2010Coated Stem Collar With Extracortical Plate Provides Excellent Long\u2010Term Results Against Aseptic Loosening in Revision, Including Short\u2010Segment, Endoprosthetic Tumour Reconstruction"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-3286","authenticated-orcid":false,"given":"Patrick Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Orthopaedics, Department of Surgery Universit\u00e9 de Montr\u00e9al  Montreal 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