{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:11:32Z","timestamp":1782738692749,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chordomas are rare tumors that arise from notochord remnants and are typically located in the axial skeleton. Chordomas arising in the lower cervical spine are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We report a case of a 79\u2010year\u2010old man who presented with a lump on the left side of his neck, indicating an unusual presentation of a chordoma in the lower cervical region. This report describes the clinical, radiological, and histological results of this patient who sought medical attention for a left\u2010sided neck mass. Additional diagnostic tests, including immunohistochemistry and biopsy, confirmed the existence of a chordoma affecting the lower cervical region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The precision of a diagnosis of cervical chordoma hinges on imaging study results and confirmation provided by histological examination, typically through biopsy and immunohistochemistry. The primary treatment for cervical chordoma is the surgical resection. Adjunctive therapies, such as radiation therapy and, in some cases, chemotherapy, may be used to manage residual disease or recurrent tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case emphasizes the rarity of lower cervical chordomas, which present as a neck mass and are a diagnostic dilemma. Total excision is complex and relies on combining multiple disciplines including imaging, immunohistochemistry, and adjunct radiation therapy. Long\u2010term follow\u2010up and early detection are key to better outcomes and reduced recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>5.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70270","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T15:09:57Z","timestamp":1752073797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower Cervical Chordomas: A Case Report and Differential Diagnosis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-9049","authenticated-orcid":false,"given":"Yosita","family":"Muenkaew","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Ramathibodi Hospital, Faculty of Medicine Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-6694","authenticated-orcid":false,"given":"Artit","family":"Jinawath","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ramathibodi Hospital, Faculty of Medicine Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7254-2654","authenticated-orcid":false,"given":"Wichit","family":"Cheewaruangroj","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Ramathibodi Hospital, Faculty of Medicine Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-11-1344"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2015.03.012"},{"key":"e_1_2_10_4_1","volume-title":"Soft Tissue and Bone Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71190-8"},{"issue":"1","key":"e_1_2_10_6_1","article-title":"A Case of Cervical Chordoma","volume":"5","author":"Nicolette M.","year":"2024","journal-title":"Cooper Rowan Medical Journal"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10051054"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"79","article-title":"Long\u2010Term Outcomes of High\u2010Dose Single\u2010Fraction Radiosurgery for Chordomas of the Spine and Sacrum","volume":"32","author":"Jin C. J.","year":"2019","journal-title":"Journal of Neurosurgery"},{"key":"e_1_2_10_9_1","first-page":"861","article-title":"Computed Tomography and Magnetic Resonance Imaging Features of Cervical Chordoma","volume":"16","author":"Cui J. F.","year":"2018","journal-title":"Oncology Letters"},{"issue":"8","key":"e_1_2_10_10_1","first-page":"1509","article-title":"Prognostic Implications of Gadolinium Enhancement of Skull Base Chordomas","volume":"39","author":"Lin E.","year":"2018","journal-title":"AJNR. American Journal of Neuroradiology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2022.02.037"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.25259\/JCIS_62_2022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0860-8"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/1793-5482.185066"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.JNS16559"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003406"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.01.057"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T23:54:38Z","timestamp":1753660478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/cnr2.70270"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70270","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70270"}}