{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:54:00Z","timestamp":1754160840506,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>) mutations in squamous cell lung carcinoma are rare. EGFR\u2010tyrosine kinase inhibitors are generally less effective for <jats:italic>EGF<\/jats:italic>R\u2010mutated squamous cell lung carcinoma. We herein present a case of <jats:italic>EGFR<\/jats:italic>\u2010mutated squamous cell lung carcinoma that responded to osimertinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 75\u2010year\u2010old woman with bloody sputum and left back pain was referred to NHO Kochi Hospital. A mass was observed in the left lower lobe on chest CT. Squamous cell lung carcinoma, cT4N1M1b (adrenal metastasis) stage IVA, was diagnosed based on the findings of a CT\u2010guided percutaneous lung biopsy and a CT scan revealing right adrenal metastasis. The primary tumor was subjected to a genomic analysis with the AmoyDx Pan Lung Cancer PCR panel, which revealed an <jats:italic>EGFR<\/jats:italic> mutation (exon 21 L858R). The PD\u2010L1 tumor proportion score was 95%. Osimertinib was initiated as first\u2010line targeted therapy. Tumor shrinkage was observed and maintained over 9 months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We encountered a rare <jats:italic>EGFR<\/jats:italic>\u2010mutated squamous cell lung carcinoma that responded well to osimertinib. Osimertinib may be an option for the treatment of patients with <jats:italic>EGFR<\/jats:italic>\u2010mutated squamous cell lung carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70273","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T04:36:52Z","timestamp":1751863012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010Line Osimertinib for <i>EGFR<\/i>\u2010Mutated Squamous Cell Lung Carcinoma: A Case Report"],"prefix":"10.1002","volume":"8","author":[{"given":"Yugo","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Hospital Organization Kochi Hospital  Kochi 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