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However, their therapeutic role in NSCLC has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>Here, we present a case of a 91\u2010year\u2010old male with metastatic NSCLC who progressed on multiple lines of treatment. Next\u2010generation sequencing revealed ATM mutations, leading to the initiation of olaparib, which successfully achieved remission over a two\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case underscores the promising role of olaparib in treating NSCLC with HRD, particularly ATM mutations, highlighting the importance of molecular testing and targeted therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70276","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:12:13Z","timestamp":1751875933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Over Two Years of Sustained Remission With Olaparib Monotherapy in Stage <scp>IV<\/scp> Non\u2010Small Cell Lung Cancer With <scp>ATM<\/scp> Mutation: A Case 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