{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:13:24Z","timestamp":1788286404660,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>As a result of the COVID\u201019 pandemic, health inequities have garnered heightened attention in the public consciousness. In particular, rural access to diagnosis and radiotherapy (RT) for pediatric oncology patients was markedly affected during this period. The fractionated nature of RT creates a transportation burden for this population. We reviewed our institutional experience with pediatric oncologic therapy at a tertiary academic center serving a primarily rural population over a large geographic area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients aged \u2264\u200918\u2009years diagnosed with cancer between 2018 and 2022 at our institution were investigated, and we identified the subset of patients who received RT at our institution. Patients were categorized as pre\u2010COVID onset (diagnosed between 2018 and January 31, 2020) or post\u2010COVID onset (diagnosed on or after January 31, 2020, to December 1st, 2022). Chi\u2010Square and Student's t\u2010tests were used to elucidate associations between patient demographics and treatment modalities in the pre\u2010 and post\u2010COVID onset groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 114 patients were identified. For patients that received RT (<jats:italic>n<\/jats:italic>\u2009=\u200922), 4.5 times more patients traveled from rural counties post\u2010COVID onset (<jats:italic>p<\/jats:italic>\u2009=\u20090.027). These patients also saw increased rates of central nervous system (CNS) and non\u2010hematologic cancer diagnosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.013 and 0.049, respectively). No difference was seen concerning race, patient age, or average distance traveled (<jats:italic>p<\/jats:italic>\u2009=\u20090.371, 0.249, and 0.420, respectively). No difference was seen in the estimated transportation cost incurred as a result of RT treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.144) or in treatment with concurrent chemotherapy (<jats:italic>p<\/jats:italic>\u2009=\u20090.245). For the entire cohort, no associations were seen concerning age, race, rural versus urban home county, cancer primary site, or in the prevalence of hematologic\u2010 or CNS\u2010based cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results highlight the importance of understanding barriers to care to improve outcomes in rural pediatric patients, as the burden of RT may be greater for these patients than for those living in urban counties. Further investigation into barriers to treatment among rural pediatric patients undergoing RT is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70277","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T04:59:17Z","timestamp":1751864357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pediatric Radiation Oncology in the Era of <scp>COVID<\/scp>\u201019: A Single Institution Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-8713","authenticated-orcid":false,"given":"Melisa","family":"Pasli","sequence":"first","affiliation":[{"name":"East Carolina University (ECU) Brody School of Medicine (BSOM)  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-8345","authenticated-orcid":false,"given":"Michael C.","family":"Larkins","sequence":"additional","affiliation":[{"name":"East Carolina University (ECU) Brody School of Medicine (BSOM)  Greenville North Carolina USA"},{"name":"Department of Emergency Medicine Boonshoft School of Medicine at Wright State University  Fairborn Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Edwards","sequence":"additional","affiliation":[{"name":"East Carolina University (ECU) Brody School of Medicine (BSOM)  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Goins","sequence":"additional","affiliation":[{"name":"East Carolina University (ECU) Brody School of Medicine (BSOM)  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayana","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"East Carolina University (ECU) Brody School of Medicine (BSOM)  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4301-021X","authenticated-orcid":false,"given":"Cathleen","family":"Cook","sequence":"additional","affiliation":[{"name":"ECU Department of Pediatrics, Division of Pediatric Hematology\/Oncology  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Ju","sequence":"additional","affiliation":[{"name":"ECU Department of Radiation Oncology  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Burke","sequence":"additional","affiliation":[{"name":"ECU Department of Radiation Oncology  Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"CDC (Centers for Disease Control and Prevention) \u201cCDC Museum COVID\u201019 Timeline \u201d(2023) https:\/\/www.cdc.gov\/museum\/timeline\/covid19.html."},{"key":"e_1_2_11_3_1","unstructured":"\u201cEnd of the Federal COVID\u201019 Public Health Emergency (PHE) Declaration CDC [Internet] \u201d(2024) https:\/\/archive.cdc.gov\/www_cdc_gov\/coronavirus\/2019\u2010ncov\/your\u2010health\/end\u2010of\u2010phe.html."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192416863"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32000-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0271049"},{"key":"e_1_2_11_8_1","first-page":"1","article-title":"The Care of Children With Cancer During the COVID\u201019 Pandemic","volume":"41","author":"Moreira D. 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