{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:54:05Z","timestamp":1754160845440,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bone marrow infiltration is a rare presentation in patients with extragonadal germinal cell tumors (EGGCTs). We report a case of primary mediastinal germ cell tumor presenting with bone marrow metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 28\u2010year\u2010old male patient was admitted to Instituto Nacional de Enfermedades Neopl\u00e1sicas with superior vena cava syndrome and a mediastinal mass accompanied by positive blood tumor markers for germinal cell tumor (GCT). In addition, he exhibited anemia and thrombocytopenia; therefore, bone marrow aspiration and biopsy were done and showed metastatic GCT cells. The patient started standard chemotherapy (bleomycin\u2010etoposide\u2010cisplatin) for 2 cycles; there was a reduction of serum tumor markers; however, the patient subsequently developed febrile neutropenia and severe pneumonia, resulting in death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case demonstrates an uncommon presentation of EGGCT with bone marrow metastases. Early detection of this presentation will help to reduce the tumor burden and the mortality associated with it.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70282","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T11:55:33Z","timestamp":1752926133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Mediastinal Germ Cell Tumor With Bone Marrow Infiltration: A Case Report and Literature Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3141-7418","authenticated-orcid":false,"given":"Patricia","family":"Rioja","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Instituto Nacional de Enfermedades Neopl\u00e1sicas (INEN)  Lima Peru"},{"name":"Oncosalud\u2013AUNA  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-4448","authenticated-orcid":false,"given":"Guillermo","family":"Valencia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Instituto Nacional de Enfermedades Neopl\u00e1sicas (INEN)  Lima Peru"},{"name":"Oncosalud\u2013AUNA  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9725-9278","authenticated-orcid":false,"given":"Zaida","family":"Morante","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Instituto Nacional de Enfermedades Neopl\u00e1sicas (INEN)  Lima Peru"},{"name":"Oncosalud\u2013AUNA  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-5243","authenticated-orcid":false,"given":"Renier","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Pathology Instituto Nacional de Enfermedades Neopl\u00e1sicas (INEN)  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-4560","authenticated-orcid":false,"given":"Tatiana","family":"Vidaurre","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Instituto Nacional de Enfermedades Neopl\u00e1sicas (INEN)  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-9853","authenticated-orcid":false,"given":"Silvia","family":"Neciosup","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Instituto Nacional de Enfermedades Neopl\u00e1sicas (INEN)  Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","unstructured":"\u201cTesticular Cancer\u2013Introduction\u2013Uroweb 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