{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:54:03Z","timestamp":1754160843679,"version":"3.41.2"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Invasive pleomorphic lobular carcinoma (IPLC) is a rare and aggressive variant of invasive lobular breast cancer, characterized by its distinct histological features and potential for metastatic spread. This case report aims to highlight the diagnostic challenges of IPLC, particularly regarding its imaging and pathological characteristics, and to review the latest treatment protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>A 43\u2010year\u2010old female presented with a painless right breast mass that had persisted for 4\u2009months. The breast ultrasound and mammography did not provide an accurate assessment, whereas MRI indicated multiple abnormal signals throughout the right breast, classified as BI\u2010RADS 4c. Surgical intervention and subsequent pathological examination confirmed the diagnosis of multifocal invasive pleomorphic lobular carcinoma with lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IPLC presents diagnostic challenges due to its rare and aggressive nature, requiring a high degree of clinical suspicion. This case underscores the importance of comprehensive imaging and pathological assessment for the accurate diagnosis and treatment of IPLC. The standard treatment involves modified radical mastectomy, lymph node dissection, and postoperative chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70285","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:27:47Z","timestamp":1753345667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and Management of Invasive Pleomorphic Lobular Carcinoma of the Breast: A Case Report and Comprehensive Review of Current Literature"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-7799","authenticated-orcid":false,"given":"Xiaoyu","family":"Sun","sequence":"first","affiliation":[{"name":"Attending Physician, MM, Department of Pathology, Zibo Central Hospital  Shandong Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1266-2588","authenticated-orcid":false,"given":"Yanze","family":"Liu","sequence":"additional","affiliation":[{"name":"Resident Physician, MM, Department of Breast and Thyroid Surgery Zibo Central Hospital  Shandong Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6110-1224","authenticated-orcid":false,"given":"Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"Nurse\u2010In\u2010Charge, BS, Zibo Central Hospital  Shandong Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5595-5988","authenticated-orcid":false,"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Attending Physician, PhD, Department of Breast and Thyroid Surgery, Zibo Central Hospital  Shandong Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-022-06627-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.11.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019182947"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00031348221101600"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6591-6"},{"key":"e_1_2_12_8_1","unstructured":"Network N C C \u201cNCCN Clinical Practice Guidelines in Oncology: Breast Cancer (Version 6.2024)[S] \u201d(2024)."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01385-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235790"},{"issue":"10","key":"e_1_2_12_11_1","article-title":"Case of HER2neu+ Invasive Pleomorphic Lobular Carcinoma With Response to Conventional Neoadjuvant Chemotherapy: A Viable Option for an Exceedingly Rare Breast Cancer Type","volume":"12","author":"Nelson B.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_12_12_1","article-title":"Pleomorphic Invasive Lobular Carcinoma of the Breast With Extracellular Mucin and HER2 Amplification","volume":"14","author":"Burky M. 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