{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:02:28Z","timestamp":1757617348184,"version":"3.44.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive ductal carcinoma (<jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content>), the most common breast cancer subtype, exhibits significant heterogeneity, limiting traditional prognostic markers. Molecular profiles improve precision, but imaging features may also reflect tumor biology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study evaluates the predictive potential and clinical applicability of ultrasound features for determining tumor grade and molecular profiles in <jats:styled-content style=\"fixed-case\">IDC.<\/jats:styled-content><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A blinded radiologist retrospectively analyzed 109 <jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content> cases using the American College of Radiology (<jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>) Breast Imaging Reporting and Data System (<jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RADS<\/jats:styled-content>) classification, evaluating ultrasound features such as lesion shape, margins, orientation, echo pattern, calcifications, vascularity, and lymph node involvement. Tumors were graded histologically (Scarff\u2010Bloom\u2010Richardson system) as low (grades 1 and 2) or high (grade 3). Immunohistochemistry determined estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki\u201067 status. ER and PR positivity were defined as &gt;\u200910% nuclear staining, HER2 graded on a 0\u20133+ scale, and Ki\u201067 positivity as \u2265\u200910% staining. Statistical analyses, including logistic and linear regression, examined correlations between ultrasound features and histological\/molecular profiles. Among 109 women (mean age 48.4\u2009\u00b1\u200912.5\u2009years), the mean tumor length and width were 21.83\u2009\u00b1\u200911.22\u2009mm and 15.3\u2009\u00b1\u20096.97\u2009mm, respectively. Histopathological grading revealed that grade 2 tumors were predominant (51%), while grade 1 and grade 3 tumors were observed in 25% and 24% of cases, respectively. ER and PR positivity were observed in 76.4% and 67.6% of cases, respectively. High\u2010grade tumors were significantly associated with ER and PR negativity (<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.05). Ultrasound features associated with high\u2010grade tumors included larger tumor length (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.029). ER positive tumors had smaller axillary lymph nodes (<jats:italic>p<\/jats:italic>\u2010value\u2009&lt;\u20090.05). Likewise, PR positive tumors exhibited smaller suspicious axillary lymph nodes compared to PR negative cases (<jats:italic>p<\/jats:italic>\u2010value\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sonographic features may correlate with histological grades and hormone receptor statuses in breast <jats:styled-content style=\"fixed-case\">IDC<\/jats:styled-content>, suggesting that ultrasound could aid in predictive assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70288","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T01:21:00Z","timestamp":1754011260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sonographic Correlations With Histological Grade and Biomarker Profiles in Breast Invasive Ductal Carcinoma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1112-459X","authenticated-orcid":false,"given":"Golnaz","family":"Moradi","sequence":"first","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiology, Sina Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-2538","authenticated-orcid":false,"given":"Nasrin","family":"Ahmadinejad","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Cancer Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5468-9235","authenticated-orcid":false,"given":"Diana","family":"Zarei","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-7731","authenticated-orcid":false,"given":"Nahid","family":"Sadighi","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_3_1","first-page":"432","volume-title":"Pathology and Genetics of Tumours of the Breast and Female Genital Organs","author":"Tavassoli F. 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