{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:02:15Z","timestamp":1757617335134,"version":"3.44.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chemotherapy\u2010induced peripheral polyneuropathy (CIPN) is a debilitating side effect of cancer treatment such as in acute lymphoblastic leukemia (ALL). Characterized by the dysfunction of the peripheral nervous system, CIPN can occur in 90% of pediatric patients, significantly impairing their quality of life. In most cases, it necessitates the modification of standard chemotherapy regimens, which can compromise the treatment efficacy and increase the risk of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We report a 16\u2010year\u2010old boy with ALL who developed CIPN during induction therapy. A multidisciplinary, individualized treatment approach combined with regular follow\u2010ups ensured optimal management. The patient achieved complete remission with significant improvement in mobility and neurological functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early recognition and comprehensive management of CIPN in pediatric ALL patients are essential to optimizing outcomes while maintaining the overall efficacy of chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70293","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T10:27:34Z","timestamp":1755685654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy\u2010Induced Peripheral Polyneuropathy in Pediatric Acute Lymphoblastic Leukemia: A Case Report on Manifestation, Management, and Outcome"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7102-9721","authenticated-orcid":false,"given":"Eman","family":"Al Mattar","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology and Stem Cell Transplant Unit NBK Specialized Children's Hospital  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-3666","authenticated-orcid":false,"given":"Sondus","family":"Al Sharidah","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology and Stem Cell Transplant Unit NBK Specialized Children's Hospital  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5262-1309","authenticated-orcid":false,"given":"Omnia A.","family":"Hashem","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology and Stem Cell Transplant Unit NBK Specialized Children's Hospital  Kuwait City Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1931"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8053.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1015746"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007853"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex229"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813491829"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12114"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.4.367"},{"key":"e_1_2_9_10_1","unstructured":"UKALL 2011 Trial United Kingdom National Randomised Trial For Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011. 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