{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:57:37Z","timestamp":1758776257508,"version":"3.44.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701202"],"award-info":[{"award-number":["2021YFC2701202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20368"],"award-info":[{"award-number":["U20A20368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>Background and Aims<\/jats:title>Human papillomavirus (HPV) vaccines have been available in China for only 8\u2009years, and routine HPV testing is not recommended prior to vaccination. Therefore, evaluation of HPV vaccine effectiveness and the impact of pre\u2010vaccination HPV infection status on vaccine protective effect in Chinese women is warranted.<\/jats:p><\/jats:sec>Methods<\/jats:title>From June 2022 to June 2023, women aged 18 to 50\u2009years without a history of cervical or uterine excision were recruited from three medical institutions. Baseline characteristics were compared between vaccinated and unvaccinated participants, with inverse probability treatment weighting (IPTW) applied to adjust for confounding factors. HPV infection rates and vaccine effectiveness (VE) were calculated. Additionally, a sub\u2010group analysis was conducted among vaccinated women to explore the impact of pre\u2010vaccination HPV infection status.<\/jats:p><\/jats:sec>Results<\/jats:title>After adjusting for group differences, the vaccine effectiveness against new HPV16\/18 infections was 76.1% (95% CI: 58.7%\u201386.2%) among 2285 participants. Older age and possession of a master's degree or higher were identified as protective factors, whereas increased parity and exclusive use of oral contraceptives were determined to be risk factors for HPV16\/18 infection. Women with unknown pre\u2010vaccination HPV status exhibited significantly higher post\u2010vaccination rates of high\u2010risk HPV infections (RR 4.278, 95% CI: 2.537\u20137.215) compared to those who were HPV\u2010negative prior to vaccination. However, no significant difference in new high\u2010risk HPV infection rates was observed between pre\u2010vaccination HPV\u2010negative and HPV\u2010positive women.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In addition to HPV vaccination, factors such as age, parity, exclusive use of oral contraceptives, and higher education attainment were independently associated with HPV16\/18 infection rates. Pre\u2010vaccination HPV infection status did not significantly influence the protective efficacy of the HPV vaccine against previously unencountered HPV types.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70294","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T02:44:53Z","timestamp":1756435493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Pre\u2010Vaccination HPV<\/scp> Status on Vaccine Effectiveness Among Chinese Women: A Multicenter Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-1586","authenticated-orcid":false,"given":"Lucia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology Xiangya Hospital, Central South University Changsha China"},{"name":"Gynecological Oncology Research and Engineering Center of Hunan Province Changsha China"},{"name":"National 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