{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:02:23Z","timestamp":1757617343377,"version":"3.44.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004598","name":"Institut de Radioprotection et de S\u00dbret\u00e9 Nucl\u00e9aire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004598","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Catheter ablation is a key treatment for atrial fibrillation (AF). This procedure is clearly identifiable in French medical\u2010administrative databases and can be used as a surrogate for symptomatic patients with drug\u2010refractory or symptomatic paroxysmal AF forms. Breast cancer (BC) patients have an increased risk of AF, but knowledge about AF forms treated by ablation is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Based on a representative cohort of BC patients from the French National Health Databases, we aimed to assess the occurrence of AF catheter ablation in these patients, compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a first diagnosis of BC between 2008 and 2018 and followed for at least 1\u2009year until 2019 were eligible. The incidence rates of AF ablation among BC patients were compared to those in the general population by estimating a standardized incidence ratio (SIR). A competing risk survival model was used to evaluate the occurrence of AF ablation in BC patients treated with or without radiotherapy (RT) (subdistribution Hazard Ratio\u2014sdHR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 3667 patients (78% with RT). Overall, 16 cases underwent AF ablation, whereas 8.3 cases were expected in the general population, resulting in a significant SIR of 1.93 [1.10\u20133.00] (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). After a mean follow\u2010up of 6.6\u2009years, the cumulative incidence of AF ablation at 5\u2009years was 0.14% [0.05\u20130.35] in the RT group and 0.47% [0.13\u20131.31] in the non\u2010RT group, with no significant difference in the age\u2010adjusted survival analysis (sdHR\u2009=\u20090.65 [0.21\u20132.01]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our exploratory study revealed that BC patients had a twofold greater rate of first AF ablation than the age\u2010comparable general population, without a link with RT. These results should be interpreted cautiously because of the limited size of the study population and the differing characteristics between the RT and non\u2010RT groups.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70320","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T04:54:29Z","timestamp":1756184069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catheter Ablation for Atrial Fibrillation in Breast Cancer Survivors: An Exploratory Observational Study Using the French Nationwide Health Care Database Sample"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-4341","authenticated-orcid":false,"given":"Laura","family":"Saint\u2010Lary","sequence":"first","affiliation":[{"name":"Autorit\u00e9 de S\u00fbret\u00e9 Nucl\u00e9aire et de Radioprotection (ASNR), PSE\u2010SANTE\/SESANE\/LEPID, Laboratoire D'\u00e9pid\u00e9miologie  Fontenay\u2010aux\u2010Roses France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Thariat","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Comprehensive Cancer Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baptiste","family":"Pinel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Clinique Pasteur  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Clinique Pasteur  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Odile","family":"Bernier","sequence":"additional","affiliation":[{"name":"Autorit\u00e9 de S\u00fbret\u00e9 Nucl\u00e9aire et de Radioprotection (ASNR), PSE\u2010SANTE\/SESANE\/LEPID, Laboratoire D'\u00e9pid\u00e9miologie  Fontenay\u2010aux\u2010Roses France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Panh","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Heart Rhythm Management Clinique Pasteur  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Boveda","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Heart Rhythm Management Clinique Pasteur  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Jacob","sequence":"additional","affiliation":[{"name":"Autorit\u00e9 de S\u00fbret\u00e9 Nucl\u00e9aire et de Radioprotection (ASNR), PSE\u2010SANTE\/SESANE\/LEPID, Laboratoire D'\u00e9pid\u00e9miologie  Fontenay\u2010aux\u2010Roses France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2021.03.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaa037"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1113231"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2372067"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2196\/40149"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009543"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.610915"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027855"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae176"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163669"},{"issue":"7","key":"e_1_2_12_12_1","article-title":"Safety and Efficacy of Colchicine for the Prevention of Post\u2010Operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Meta\u2010Analysis of Randomized Controlled Trials","volume":"25","author":"Agarwal S.","year":"2023","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4233"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100936"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab745"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-022-01341-7"},{"issue":"18","key":"e_1_2_12_18_1","first-page":"316","article-title":"The Screening, 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