{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:23:41Z","timestamp":1788621821191,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>YRDC has emerged as a potential biomarker in cancer, yet its prognostic value, oncogenic mechanisms, role in immune infiltration, and anticancer drugs efficacy in pan\u2010cancer remained poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to comprehensively investigate YRDC's role in pan\u2010cancer and to explore the potential effects of YRDC on the immune infiltration pattern and anticancer drug sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Based on bioinformatics analysis of multi\u2010omics data, we firstly demonstrated that YRDC was markedly overexpressed and associated with worse prognosis in various tumors. Further, our results indicated that genetic alterations, copy number variations, and methylation levels of YRDC might explain the different YRDC expression between tumors and controls. Additionally, YRDC might promote cancer via enhancing tumor cell proliferation, modulating immune cell infiltration, and enhancing drug resistance. Notably, YRDC emerged as a potential biomarker for predicting immunotherapy response and targeted drug efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study identifies YRDC as a novel therapeutic target and a promising biomarker for cancer progression, immunotherapy response, and targeted drug sensitivity across pan\u2010cancers. These findings provide evidence for further research into YRDC's role in cancer biology and future clinical exercises.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70325","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:22:02Z","timestamp":1756873322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>YRDC<\/scp> is a Prognostic\u2010Related Biomarker Correlated With Immune Infiltration and Drug Sensitivity in Pan\u2010Cancer"],"prefix":"10.1002","volume":"8","author":[{"given":"Li","family":"Qiao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer Sun Yat\u2010sen University Cancer Center  Guangzhou China"},{"name":"Department of Rehabilitation Medicine Nanfang Hospital, Southern Medical University  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