{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:59:39Z","timestamp":1758776379342,"version":"3.44.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postpartum placental choriocarcinoma is a rare gestational trophoblastic tumor, with an incidence of approximately one in 50\u2009000. Patients often present with persistent postpartum hemorrhage, which can lead to delayed diagnosis, hematogenous metastasis, and ultimately, a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 35\u2010year\u2010old woman was admitted to the Emergency Department 39\u2009days after a cesarean section due to persistent heavy vaginal bleeding. Initial evaluation revealed a serum \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) level of 7868\u2009mIU\/mL, transvaginal ultrasound identified a vascularized uterine mass with myometrial invasion, and MRI suggested residual tissue implantation. Following exclusion of retained products of conception, postpartum choriocarcinoma was suspected. The patient underwent five cycles of FAV chemotherapy (fluorouracil\u2009+\u2009actinomycin D\u2009+\u2009vincristine), resulting in undetectable \u03b2\u2010hCG levels and resolution of imaging findings after two cycles. Three additional consolidation cycles were administered, with complete remission confirmed at the final follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pregnancy\u2010related causes must always be ruled out in women of childbearing age who present with irregular vaginal bleeding, even during the postpartum and lactation periods. In patients with postpartum bleeding, vigilance should be heightened to rule out the possibility of a pregnancy\u2010related Sertoli cell tumor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70328","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T02:37:24Z","timestamp":1756435044000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Diagnosis and Treatment of Early Postpartum Choriocarcinoma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-1873","authenticated-orcid":false,"given":"Zeqing","family":"Du","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1267-8438","authenticated-orcid":false,"given":"Luyang","family":"Su","sequence":"additional","affiliation":[{"name":"Physical Examination Center Hebei General Hospital  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-1910","authenticated-orcid":false,"given":"Sufen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7219-3119","authenticated-orcid":false,"given":"Shizhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Second Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037510"},{"issue":"10","key":"e_1_2_12_3_1","first-page":"819","article-title":"Postpartum Choriocarcinoma Presentation, Management and Survival","volume":"51","author":"Nugent D.","year":"2006","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2383-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004240"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-023-03820-5"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/17530050903032646"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb11429.x"},{"issue":"5","key":"e_1_2_12_9_1","first-page":"213","article-title":"Choriocarcinoma After a Nonterm Pregnancy","volume":"55","author":"Macdonald M. 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