{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:57:30Z","timestamp":1758776250379,"version":"3.44.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Colorectal cancer (CRC) screening and early detection reduce mortality. Curative treatment is based on surgical resection, and pathological analysis plays a key role in management. In Lebanon, the impact of the COVID\u201019 pandemic on healthcare has been compounded by an unprecedented socio\u2010economic crisis in 2020. This has deteriorated access to medical care and could have delayed CRC diagnosis and treatment. The study evaluates the impact of the economic collapse on CRC in Lebanon by comparing characteristics of patients operated on in 2020 and 2021 (post\u2010crisis period) to those operated on in 2018 and 2019 (pre\u2010crisis period).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included patients who underwent surgical resection for colorectal adenocarcinoma at a tertiary care center in Lebanon between 01\/01\/2018 and 12\/31\/2021. Patients were divided into two groups according to the corresponding period, and the demographic, clinical, and pathological characteristics were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 169 patients included, 89 (53%) were operated on in the pre\u2010crisis period and 80 (47%) in the post\u2010crisis period. We reported that in the post\u2010crisis period: more patients presented with clinical complications requiring urgent admission (30% vs. 16%), more tumors were classified as T4b (10% vs. 2%), and more tumors presented lymphatic emboli (65% vs. 45%), perineural (51% vs. 22%) and perivascular invasion (40% vs. 19%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the worsening of clinical and pathological indicators of poor prognosis by the current economic crisis, and this could potentially be translated into a reduction of survival.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70329","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T07:51:03Z","timestamp":1757404263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colorectal Cancer Surgical Pathology: Comparative Study in\u00a0Lebanon Before and After the Economic Collapse"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-6779","authenticated-orcid":false,"given":"Georges","family":"Ayoub","sequence":"first","affiliation":[{"name":"Faculty of Medicine Saint Joseph University of Beirut  Beirut Lebanon"},{"name":"Oncologic Pathology Department Dana Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Anatomic\u2010Pathology Department Hotel Dieu de France Hospital, Saint Joseph University of Beirut  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhea","family":"Khazen","sequence":"additional","affiliation":[{"name":"Anatomic\u2010Pathology Department Hotel Dieu de France Hospital, Saint Joseph University of Beirut  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"Berberi","sequence":"additional","affiliation":[{"name":"Anatomic\u2010Pathology Department Hotel Dieu de France Hospital, Saint Joseph University of Beirut  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Trak","family":"Smayra","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Saint Joseph University of Beirut  Beirut Lebanon"},{"name":"Anatomic\u2010Pathology Department Hotel Dieu de France Hospital, Saint Joseph University of Beirut  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08261-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-019-00284-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2024.01.208"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(02)00029-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28794"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00005-4"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.2617"},{"issue":"1","key":"e_1_2_11_11_1","first-page":"167","article-title":"Changes in Cancer\u2010Related Mortality During the COVID\u201019 Pandemic in the United States","volume":"116","author":"Zhao J.","year":"2022","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.15662"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.43119"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.26334"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31908-5"},{"key":"e_1_2_11_16_1","unstructured":"Arabianbusiness Lebanese Pound: The Most Undervalued Currency in the World \u2010 Arabian Business. 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