{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:57:30Z","timestamp":1758776250001,"version":"3.44.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Human papillomavirus (HPV) infection is associated with tonsillar and base\u2010of\u2010tongue squamous cell carcinomas (TSCC\/BOTSCC). We evaluated the relative risk (RR) of TSCC\/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC\/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar\/vaginal, cervical) cancer or cervical carcinoma in\u00a0situ (CIS) as compared to husbands of controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The RR of TSCC\/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002\u20132015, the RR peaked at 5.35 (95% CI 2.21\u201313.0) in TSCC\/BOTSCC cases diagnosed at age &lt;\u200950\u2009years. In husbands of women with CIS, the RR for TSCC\/BOTSCC was 2\u2010fold irrespective of time period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clustering of increased HPV\u2010associated invasive cancer risk in spouses appears to be calendar\u2010time dependent. This introduces a new perspective in cancer science: an increase of familial HPV\u2010associated cancer risk in spouses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cnr2.70333","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T02:35:21Z","timestamp":1756434921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Risk of <scp>HPV<\/scp>\u2010Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-422X","authenticated-orcid":false,"given":"Tuomas","family":"Lehtinen","sequence":"first","affiliation":[{"name":"FICAN\u2010Mid Tampere University  Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luayo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Genetic Epidemiology Division Deutsches Krebsforschungszentrum (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Center for Community\u2010Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine Shimane University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Center for Community\u2010Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine Shimane University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Waterboer","sequence":"additional","affiliation":[{"name":"Infections and Cancer Epidemiology Division Deutsches Krebsforschungszentrum (DKFZ)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-0535","authenticated-orcid":false,"given":"Matti","family":"Lehtinen","sequence":"additional","affiliation":[{"name":"Infections and Cancer Epidemiology Division Deutsches Krebsforschungszentrum (DKFZ)  Heidelberg Germany"},{"name":"Department of Laboratory Medicine Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[{"name":"Molecular Genetic Epidemiology Division Deutsches Krebsforschungszentrum (DKFZ)  Heidelberg Germany"},{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Faculty of Medicine and Biomedical Center in Pilsen Charles University in Prague  Pilsen Czech 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