{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:31:39Z","timestamp":1789144299402,"version":"build-2803163510"},"reference-count":87,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vascular endothelial growth factor\u2010A (VEGF\u2010A), In combination with other pro\u2010angiogenic factors, plays a pivotal role in angiogenesis and the pathogenesis of acute lymphoblastic leukemia (ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This meta\u2010analysis aims to evaluate the diagnostic value of VEGF\u2010A and its prognostic relevance in the outcome of patients with ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was conducted up to January 2025 across multiple databases. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were pooled using a random\u2010effects model to quantify effect sizes. Subgroup analyses and meta\u2010regression were employed to explore heterogeneity sources. Data extracted from 15 studies encompassing 674 patients with ALL demonstrated a significant correlation between elevated VEGF\u2010A levels and unfavorable prognosis (SMD: 0.878; 95% CI: 0.276\u20131.479;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). Notably, increased VEGF\u2010A levels were particularly evident in pediatric patients older than 8\u2009years (SMD: 0.758; 95% CI: 0.178\u20131.338;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results indicate that heightened VEGF\u2010A expression is associated with poorer clinical outcomes in ALL, supporting its utility as a diagnostic and prognostic biomarker in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70351","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T07:49:46Z","timestamp":1757749786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Update Prognostic Potency of Vascular Endothelial 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