{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:06:00Z","timestamp":1761624360073,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The Treatment of Metastatic Castration\u2010Sensitive Prostate Cancer (\n mCSPC<\/jats:styled-content>\n ) has dramatically changed over the past decade. To improve oncological outcomes, pharmacological treatments have evolved to include two\u2010or three\u2010drug combinations, and the efficacy of local radiation therapy (\n LRT<\/jats:styled-content>\n ) at the prostate combined with denosumab chemotherapy has been discussed.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n This study aimed to provide an interim evaluation of the combination of androgen receptor signaling inhibitors denosumab,\n LRT<\/jats:styled-content>\n , and metastasis\u2010directed therapy (\n MDT<\/jats:styled-content>\n ) for prostate cancer with multiple bone metastases (poly\u2010\n PCa<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We are currently conducting a single\u2010arm prospective study to evaluate the combination of enzalutamide,\n LRT<\/jats:styled-content>\n , denosumab, and\n MDT<\/jats:styled-content>\n in terms of improving oncological outcomes in patients with poly\u2010\n PCa<\/jats:styled-content>\n . The primary endpoints were prostate\u2010specific antigen (\n PSA<\/jats:styled-content>\n )\u2010based progression\u2010free survival (\n PFS<\/jats:styled-content>\n ) and radiographic\n PFS<\/jats:styled-content>\n (\n rPFS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty patients have been enrolled in the study to date. The median follow\u2010up period thus far is 18.0\u2009months (interquartile range, 14.0\u201325.8\u2009months). The 1\u2010year\n PFS<\/jats:styled-content>\n rate is 84.4% at present, and the\n rPFS<\/jats:styled-content>\n rate is 100%. Seventeen patients (85.0%) achieved a\n PSA<\/jats:styled-content>\n reduction of \u2265\u200990% versus their baseline values at enrollment, and 10 (50.0%) maintained\n PSA<\/jats:styled-content>\n levels of <\u20090.2\u2009ng\/\n mL<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This treatment strategy is expected to improve the oncological outcomes of patients with poly\u2010\n PCa<\/jats:styled-content>\n . A more comprehensive report of this study with more patients and a longer observation period is forthcoming.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cnr2.70355","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:45:33Z","timestamp":1759315533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Combination Androgen\u2010Receptor Signaling Inhibitors, Denosumab, and Local Radiotherapy for Poly\u2010Metastatic Prostate Cancer"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-2462","authenticated-orcid":false,"given":"Makoto","family":"Kawase","sequence":"first","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine Gifu 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-1722","authenticated-orcid":false,"given":"Keita","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-127X","authenticated-orcid":false,"given":"Takuya","family":"Koie","sequence":"additional","affiliation":[{"name":"Department of Urology Gifu University Graduate School of Medicine Gifu 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