{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:07:44Z","timestamp":1761624464435,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immunotherapy is well\u2010established in treating metastatic non\u2010small cell lung cancer (mNSCLC); however, data regarding acquired resistance and long\u2010term outcomes are limited. We examined long\u2010term outcomes in mNSCLC patients with ongoing treatment response at 2\u2009years (long\u2010term responders) post\u2010treatment commencement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi\u2010center retrospective study identified mNSCLC patients treated with first\u2010 or second\u2010line immunotherapy\u00b1chemotherapy. Endpoints included progression\u2010free survival (PFS) and overall survival (OS), stratified by PD\u2010L1 tumor proportion score (TPS) (&lt;\u200950% vs. \u2265\u200950%), treatment duration, and treatment line.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 354 patients, 52 (15%) long\u2010term responders were identified for analysis. Among them, median age was 68.5\u2009years (28\u201387); the majority had an ECOG performance status \u2264\u20091 (81%), high\u2010PD\u2010L1 TPS (52%), and adenocarcinoma histopathology (83%). Most (73%) received immunotherapy first\u2010line. Median treatment duration was 23.5\u2009months (1\u201380), and 19% prematurely ceased treatment. With a median follow\u2010up of 39\u2009months from treatment commencement (95% CI 37\u201349), 15 (29%) patients had progressive disease, and 3\u2010year PFS was 78%. Oligo\u2010progression was common (87%), with lung\/pleural disease (53%). Most received subsequent treatment (local therapy alone: 53%, systemic therapy alone: 20%, combined: 20%, supportive care: 7%) and achieved disease control (86%). Long\u2010term toxicities occurred in 44% and were predominantly endocrinopathies (83%) requiring ongoing management. Three\u2010year OS was 93%. Survival outcomes were unaffected by treatment duration, PD\u2010L1 TPS, and treatment line.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Long\u2010term responders showed favorable survival outcomes, with most maintaining disease control with local therapies even after progression. This held true regardless of treatment duration, PD\u2010L1 TPS, or treatment line. Endocrinopathies were common long\u2010term toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70361","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T23:44:46Z","timestamp":1759967086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Outcomes and Toxicities in Patients With Metastatic Non\u2010Small Cell Lung Cancer Treated With Immunotherapy Containing Regimens"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4819-9397","authenticated-orcid":false,"given":"Meghana","family":"Maddula","sequence":"first","affiliation":[{"name":"Crown Princess Mary Cancer Centre, Westmead Hospital  Sydney New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"The Kinghorn Cancer Centre, St Vincent's Hospital  Sydney New South Wales 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